Queensland Alliance for Environmental Health Sciences, The University of Queensland, 20 Cornwall Street, Woolloongabba, Queensland 4102, Australia.
Advanced Water Management Centre, The University of Queensland, St Lucia, Queensland 4072, Australia.
Sci Total Environ. 2020 Mar 20;709:136228. doi: 10.1016/j.scitotenv.2019.136228. Epub 2019 Dec 20.
Wastewater-based epidemiology is an increasingly popular method for analysing drugs or metabolites excreted by populations. The in-sewer transformation of biomarkers is important but often receives little consideration in published studies. Many studies publish stability under biofilm-free conditions only, which do not represent actual sewer conditions. This study aims to fill a gap in the field by comparing the wastewater stability of 33 licit drug and pharmaceutical biomarkers in biofilm-free (BFF) conditions to stability in sewer biofilm reactors. All but one biomarker was stable under BFF conditions, whereas most transformed in sewer biofilm reactors. Sewer reactor results tended to overestimate the degradation in pilot and actual sewers, whereas BFF stability had no clear relationship to stability in pilot and actual sewers. Our results provide additional basis for more informed interpretation of biofilm-free and sewer reactor stability results for past and future WBE studies.
基于污水的流行病学是一种越来越受欢迎的分析人群排泄的药物或代谢物的方法。生物标志物在污水中的转化很重要，但在已发表的研究中往往很少考虑。许多研究仅在无生物膜条件下发表稳定性数据，而这些数据不能代表实际的污水条件。本研究旨在通过将 33 种合法药物和药物生物标志物在无生物膜（BFF）条件下的污水稳定性与在污水生物膜反应器中的稳定性进行比较，来填补该领域的空白。除了一种生物标志物外，所有生物标志物在无生物膜条件下均稳定，而大多数生物标志物在污水生物膜反应器中发生转化。污水反应器的结果往往高估了中试和实际污水中的降解情况，而无生物膜稳定性与中试和实际污水中的稳定性没有明显关系。我们的结果为更明智地解释过去和未来 WBE 研究中的无生物膜和污水反应器稳定性结果提供了更多依据。
