Research Department of Practice and Policy, UCL School of Pharmacy, University College London, London, UK.
Faculty of Medicine, Department of Brain Sciences, Imperial College London, London, UK.
BMJ Open. 2019 Sep 20;9(9):e031707. doi: 10.1136/bmjopen-2019-031707.
To survey current prescribing practices of psychotropic drugs by child and adolescent eating disorder (CAED) psychiatrists in the treatment of anorexia nervosa (AN).
Cross-sectional self-administered survey.
All children and young people eating disorder services (CYP EDS) in England during a national training programme.
44 CAED psychiatrists practising in CYP EDS in England.
CAED psychiatrists completed a questionnaire regarding the pattern of psychopharmacological care in AN that they provide and the medication treatment pattern at their CYP EDS. Secondary outcome measures included the process of continuing pharmacotherapy from secondary care to primary care.
Of the 77 CYP EDS representing every team in England, 44 teams represented by a CAED psychiatrist responded, despite 13 having no psychiatrists in post at the time of the study (response rate 69%). Most (40%) respondents estimated that <10% of patients with AN were prescribed psychotropic medications. Olanzapine was reported as the most commonly prescribed medication for AN by 38% of the respondents, followed by fluoxetine (29%) and sertraline (10%). The most common minimum olanzapine initiation dose in this study was at 2.5 mg/day for a duration of 2-4 weeks, reaching a maximum dose of 5 mg/day. Most (68%) reviewed medications every week (30%) or every 2 weeks (38%). Over 50% of the respondents reported continuation of olanzapine prescribing within the CYP EDS teams.
This nationally representative survey showed that despite a lack of evidence, psychotropic medications are commonly prescribed to a minority of patients, most frequently, olanzapine. Further evidence is needed on which patients may potentially benefit from pharmacotherapy as an adjunct to psychological interventions.
调查儿童和青少年进食障碍(CAED)精神科医生在治疗神经性厌食症(AN)时使用精神药物的处方习惯。
横断面自我管理调查。
英格兰所有儿童和青少年进食障碍服务(CYP EDS)在国家培训计划期间。
在英格兰 CYP EDS 执业的 44 名 CAED 精神科医生。
CAED 精神科医生完成了一份关于他们在 AN 中提供的精神药理学护理模式以及 CYP EDS 中的药物治疗模式的问卷。次要结果措施包括从二级护理到初级护理的连续药物治疗过程。
尽管在研究期间有 13 个团队没有精神科医生,但代表英格兰每个团队的 77 个 CYP EDS 中有 44 个团队由 CAED 精神科医生代表,回应率为 69%(响应率 69%)。大多数(40%)受访者估计,接受 AN 治疗的患者中只有不到 10%的患者服用精神药物。38%的受访者报告奥氮平是 AN 最常开的药物,其次是氟西汀(29%)和舍曲林(10%)。在这项研究中,最常见的奥氮平起始剂量为 2.5mg/天,持续 2-4 周,最大剂量为 5mg/天。大多数(68%)受访者每周(30%)或每两周(38%)审查一次药物。超过 50%的受访者报告在 CYP EDS 团队中继续开奥氮平处方。
这项具有全国代表性的调查显示,尽管缺乏证据,但精神药物在少数患者中经常开处方,最常开的是奥氮平。需要进一步的证据来确定哪些患者可能从作为心理干预辅助的药物治疗中受益。