1997 年至 2009 年神经性厌食症患者的精神药物使用情况。
Psychotropic medication use in anorexia nervosa between 1997 and 2009.
机构信息
Neuroendocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
出版信息
Int J Eat Disord. 2012 Dec;45(8):970-6. doi: 10.1002/eat.22037. Epub 2012 Jun 26.
OBJECTIVE
Despite a lack of data demonstrating benefit, psychotropic medications are frequently prescribed for patients with anorexia nervosa.
METHOD
We studied 525 women (18-54 years of age) with anorexia nervosa who presented to the Clinical Research Center at the Massachusetts General Hospital between January 1997 and December 2009. For this analysis, participants were a priori divided into two groups based on date of presentation (Group I: participants presenting between 1997 and 2002; Group II: participants presenting between 2003 and 2009).
RESULTS
Overall, 53% of participants reported current use of any psychotropic medication; 48.4% reported use of an antidepressant and 13% reported use of an antipsychotic. Twice as many participants in Group II (18.5%) reported using atypical antipsychotics as compared to Group I (8.9%) (p = 0.002).
DISCUSSION
A majority of participants with anorexia nervosa report using psychotropic medications despite lack of data supporting their efficacy. These data are concerning given the known adverse effects of these medications.
目的
尽管缺乏数据表明其有益，但精神药物经常被开给神经性厌食症患者。
方法
我们研究了 525 名年龄在 18-54 岁之间的神经性厌食症女性患者，她们于 1997 年 1 月至 2009 年 12 月在马萨诸塞州总医院临床研究中心就诊。基于就诊时间，本分析将参与者分为两组（I 组：1997 年至 2002 年就诊者；II 组：2003 年至 2009 年就诊者）。
结果
总体而言，53%的参与者报告正在使用任何精神药物；48.4%报告使用抗抑郁药，13%报告使用抗精神病药。与 I 组（8.9%）相比，II 组（18.5%）报告使用非典型抗精神病药的参与者多一倍（p = 0.002）。
讨论
尽管缺乏数据支持其疗效，但大多数神经性厌食症患者仍报告使用精神药物。鉴于这些药物已知的不良反应，这些数据令人担忧。
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