Canonica G W, Mingari M C, Melioli G, Colombatti M, Moretta L
J Immunol. 1979 Dec;123(6):2669-72.
Reduced numbers of T cells with Fc receptors for IgG (TG cells) are present in blood samples of patients with respiratory allergic disease, mainly those with severe symptoms. TG cells have been previously shown to be suppressor in the pokeweed mitogen- (PWM) dependent B cell differentiation. T cells with Fc receptor for IgM (TM cells), which help immunoglobulin production, are in a normal range. After specific hyposensitization, resulting in a sharp improvement of clinical symptoms, TG cell subset reached normal values.
患有呼吸道过敏性疾病的患者，主要是那些症状严重的患者，其血液样本中具有IgG Fc受体的T细胞（TG细胞）数量减少。先前已证明TG细胞在依赖商陆有丝分裂原（PWM）的B细胞分化中起抑制作用。具有IgM Fc受体的T细胞（TM细胞）有助于免疫球蛋白的产生，其数量处于正常范围。经过特异性减敏治疗后，临床症状大幅改善，TG细胞亚群达到正常值。
