Baykal Can, Atci Tugba, Buyukbabani Nesimi, Kutlay Armagan
Department of Dermatology and Venereology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.
Department of Pathology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.
Indian J Dermatol. 2019 Sep-Oct;64(5):392-399. doi: 10.4103/ijd.IJD_217_18.
The frequency of clinicoepidemiological variants of Kaposi's sarcoma (KS) differs markedly throughout the world. The iatrogenic variant is mainly associated with the use of immunosuppressive therapy.
We aimed to investigate the distribution of KS variants in our practice and elucidate the underlying causes of iatrogenic KS.
Consecutive KS patients seen in a single tertiary center were grouped according to the tumor variants and iatrogenic KS patients were evaluated about associated conditions.
Among 137 patients, classic variant was the most frequent presentation ( = 88), followed by iatrogenic ( = 37) variant. Among the iatrogenic group, ten were transplant recipients. In 16 iatrogenic KS patients, systemic corticosteroid was used, in four for myasthenia gravis (MG) and in three for rheumatoid arthritis. In three patients, KS developed under topical corticosteroid (TC) treatment. Among iatrogenic KS patients, ten of them had a second primary neoplasm and one had congenital immunodeficiency syndrome.
Our study revealed one of the highest rates for iatrogenic KS (27%) reported in the literature. Besides well-known causes, relatively frequent association with MG was remarkable. Usage of different forms of TCs was the cause of KS in a few cases.
卡波西肉瘤（KS）临床流行病学变体的发生率在世界各地存在显著差异。医源性变体主要与免疫抑制治疗的使用有关。
我们旨在调查我院KS变体的分布情况，并阐明医源性KS的潜在病因。
在单一三级中心连续就诊的KS患者根据肿瘤变体进行分组，并对医源性KS患者的相关情况进行评估。
137例患者中，经典变体最为常见（n = 88），其次是医源性变体（n = 37）。在医源性组中，10例为移植受者。16例医源性KS患者使用了全身性皮质类固醇，其中4例用于治疗重症肌无力（MG），3例用于治疗类风湿性关节炎。3例患者在局部皮质类固醇（TC）治疗下发生KS。在医源性KS患者中，10例有第二种原发性肿瘤，1例患有先天性免疫缺陷综合征。
我们的研究显示，医源性KS的发生率是文献报道中最高的之一（27%）。除了众所周知的病因外，与MG相对频繁的关联也很显著。在少数情况下，不同形式的TC的使用是KS的病因。
