Sadeghian Rastin, Rohani Bita, Golestannejad Zahra, Sadeghian Saeid, Mirzaee Shahla
Department of Orthodontics, Dental School, Aja University of Medical Sciences, Tehran, Iran.
Department of Oral Medicine, Dental School, Aja University of Medical Sciences, Tehran, Iran.
Dent Res J (Isfahan). 2019 Sep 5;16(5):277-282. eCollection 2019 Sep-Oct.
Oral lichen planus (OLP) is a chronic disease without any definitive treatment. Local corticosteroids are often prescribed, but their efficacy has been questioned by many studies. The purpose of this study was to investigate the effect of nano-based triamcinolone acetonide gel (NT) and compare it with conventional triamcinolone gel (CT) on OLP.
In this triple-blind randomized clinical trial study, 40 patients with Erosive OLP were divided into two groups receiving (CT) and (NT). The patients were requested to apply them four times a day for 2 weeks. The severity of pain was evaluated through visual analog scale, the size of lesions was measured with paper lace, and the appearance of lesions was examined adopting Thongprasom scale . Findings will be significant via independent -test or Chi-square test with < 0.05.
The severity of pain in NT group was 4.9 ± 0.7 cm before the treatment and 1.5 ± 0.9 after that, whereas in CT group, it was 4.9 ± 0.8 and 1.8 ± 0.9, respectively . The mean size of the lesions in NT group was 2.1 ± 1.1 cm before the treatment and 0.8 ± 1.1 afterward, whereas in CT group, was 2.2 ± 1.1 and 1.3 ± 1.1, respectively. The OLP appearance before and after the study in NT group was 4.5 ± 0.5 and 0.8 ± 0.6, respectively, whereas in CT group was 4.6 ± 0.5 and 0.9 ± 0.7 ( = 0.3). Among these variables, only Thongprasom scale on the 6 and 14 days had a significant reduction in NT group in comparison with CT group.
NT has a better impact on OLP in comparison with CT, but this difference is not statistically significant.
口腔扁平苔藓（OLP）是一种尚无确切治疗方法的慢性疾病。局部使用皮质类固醇药物是常用的治疗手段，但许多研究对其疗效提出了质疑。本研究旨在探讨纳米曲安奈德凝胶（NT）对OLP的治疗效果，并与传统曲安奈德凝胶（CT）进行比较。
在这项三盲随机临床试验研究中，40例糜烂型OLP患者被分为两组，分别接受（CT）和（NT）治疗。要求患者每天涂抹4次，持续2周。通过视觉模拟量表评估疼痛程度，用纸片测量病损大小，采用通普拉松量表检查病损外观。当P<0.05时，通过独立样本t检验或卡方检验得出的结果将具有显著性。
NT组治疗前疼痛程度为4.9±0.7cm，治疗后为1.5±0.9cm；而CT组治疗前为4.9±0.8cm，治疗后为1.8±0.9cm。NT组病损平均大小治疗前为2.1±1.1cm，治疗后为0.8±1.1cm；CT组治疗前为2.2±1.1cm，治疗后为1.3±1.1cm。NT组研究前后OLP外观分别为4.5±0.5和0.8±0.6，CT组为4.6±0.5和0.9±0.7（P=0.3）。在这些变量中，与CT组相比，NT组仅在第6天和第14天的通普拉松量表评分有显著降低。
与CT相比，NT对OLP有更好的疗效，但这种差异无统计学意义。
