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Dowling-Degos病——一种罕见疾病的新表现形式。

Dowling-Degos Disease - A Novel Presentation of An Uncommon Disease.

作者信息

Mohanty Prasenjeet, Jain Sonal, Mohapatra Liza, Acharya Srikanta

机构信息

Department of Skin and VD, SCB Medical College and Hospital, Cuttack, Odisha, India.

出版信息

Indian Dermatol Online J. 2019 Aug 28;10(5):587-590. doi: 10.4103/idoj.IDOJ_460_18. eCollection 2019 Sep-Oct.

DOI:10.4103/idoj.IDOJ_460_18
PMID:31544084
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6743403/
Abstract

Dowling-Degos Disease is a rare, pigmentary disorder with variable presentations. The most common among them are hyperpigmented macules and reticulate pigmentary anomaly of flexures. Many other phenotypic variations of Dowling-Degos disease have been reported in literature. We present here a case of Dowling-Degos disease with comedo-like lesions and pits without typical flexural hyperpigmented macules.

摘要

Dowling-Degos病是一种罕见的色素沉着性疾病，表现多样。其中最常见的是色素沉着斑和屈侧网状色素异常。文献中还报道了Dowling-Degos病的许多其他表型变异。我们在此报告一例伴有粉刺样损害和凹坑但无典型屈侧色素沉着斑的Dowling-Degos病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a197/6743403/fd7a2a0d650c/IDOJ-10-587-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a197/6743403/2d8e8cce65c1/IDOJ-10-587-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a197/6743403/443e217f9fcf/IDOJ-10-587-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a197/6743403/f5373526e294/IDOJ-10-587-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a197/6743403/fd7a2a0d650c/IDOJ-10-587-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a197/6743403/2d8e8cce65c1/IDOJ-10-587-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a197/6743403/443e217f9fcf/IDOJ-10-587-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a197/6743403/f5373526e294/IDOJ-10-587-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a197/6743403/fd7a2a0d650c/IDOJ-10-587-g004.jpg

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Dowling-Degos Disease - A Novel Presentation of An Uncommon Disease.Dowling-Degos病——一种罕见疾病的新表现形式。
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引用本文的文献

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Unraveling Dowling-Degos Disease: A Rare Skin Disorder.解析道林-德戈斯病：一种罕见的皮肤疾病。
Clin Case Rep. 2025 Jul 14;13(7):e70643. doi: 10.1002/ccr3.70643. eCollection 2025 Jul.
2
Dowling-Degos disease in a 23-year-old Jordanian male: a case report.一名23岁约旦男性的道林-迪戈斯病：病例报告。
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本文引用的文献

1
Familial dyskeratotic comedones: A rare entity.家族性角化不良性粉刺：一种罕见病症。
Indian Dermatol Online J. 2016 Jan-Feb;7(1):46-8. doi: 10.4103/2229-5178.174308.
2
Follicular Dowling Degos disease: a rare variant of an evolving dermatosis.滤泡性 Dowling-Degos 病：一种不断演变的皮肤病的罕见变异型。
Indian J Dermatol Venereol Leprol. 2013 Nov-Dec;79(6):802-4. doi: 10.4103/0378-6323.120734.
3
Generalized dowling-degos disease: case reports.泛发性道林-德戈斯病：病例报告
Ann Dermatol. 2013 Aug;25(3):360-4. doi: 10.5021/ad.2013.25.3.360. Epub 2013 Aug 13.
4
Treatment of Dowling-Degos disease with fractional Er:YAG laser.剥脱性铒激光治疗色素性紫癜性皮病。
J Cosmet Laser Ther. 2013 Dec;15(6):336-9. doi: 10.3109/14764172.2013.764437. Epub 2013 Mar 6.
5
Presentation of reticulate acropigmentation of kitamura and dowling-degos disease overlap.北村网状肢端色素沉着症与色素性紫癜性皮病重叠的表现。
J Clin Aesthet Dermatol. 2012 May;5(5):41-3.
6
Galli-Galli disease is an acantholytic variant of Dowling-Degos disease: additional genetic evidence in a German family.加里-加里病是道林-德戈斯病的一种棘层松解变异型：一个德国家庭的额外遗传学证据。
J Am Acad Dermatol. 2012 Jun;66(6):e250-1. doi: 10.1016/j.jaad.2011.07.038.
7
A Case of Familial Comedonal Darier's Disease.一例家族性粉刺样 Darier 病
Ann Dermatol. 2011 Dec;23(Suppl 3):S398-401. doi: 10.5021/ad.2011.23.S3.S398. Epub 2011 Dec 27.
8
Three cases of Dowling Degos disease in two families.两家族中的三例 Dowling Degos 病。
Indian J Dermatol Venereol Leprol. 2009 Jul-Aug;75(4):398-400. doi: 10.4103/0378-6323.53139.
9
Generalized Dowling-Degos disease.泛发性道林-德戈斯病
J Am Acad Dermatol. 2007 Aug;57(2):327-34. doi: 10.1016/j.jaad.2006.12.023.
10
Loss-of-function mutations in the keratin 5 gene lead to Dowling-Degos disease.角蛋白5基因的功能丧失突变会导致道林-迪戈斯病。
Am J Hum Genet. 2006 Mar;78(3):510-9. doi: 10.1086/500850. Epub 2006 Jan 19.