• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

针对接受放射性碘治疗的甲状腺疾病患者，采用唾液腺穿刺术治疗口干症的疗效初步研究。

Preliminary study on the efficacy of xerostomia treatment with sialocentesis targeting thyroid disease patients given radioiodine therapy.

作者信息

Kim Euy-Hyun, Lee Dong-Keon, Kim Chang-Woo, Song In-Seok, Jun Sang-Ho

机构信息

Department of Oral and Maxillofacial Surgery, Korea University Anam Hospital, 73, Inchon-ro, Seongbuk-gu, Seoul, Republic of Korea.

出版信息

Maxillofac Plast Reconstr Surg. 2019 Sep 5;41(1):39. doi: 10.1186/s40902-019-0223-3. eCollection 2019 Dec.

DOI:10.1186/s40902-019-0223-3
PMID:31544098
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6728110/
Abstract

BACKGROUND

Radioiodine therapy has been widely used for thyroid disease patients, but hyposalivation and xerostomia may occur in 10~30% of patients. Sialocentesis is a procedure that removes inflammatory substances in the salivary duct and expands the duct for the secretion and delivery of saliva. In this study, thyroid disease patients treated with radioactive iodine were selected among the patients with xerostomia who visited the hospital, and the effect of sialocentesis was compared and analyzed. And then, comparison between the radioiodine therapy-experienced group and the non-radioiodine therapy-experienced group was conducted.

RESULTS

In this study, we studied xerostomia patients who underwent radioiodine therapy due to thyroid diseases and who underwent sialocentesis at the Korea University Anam Hospital. Sialocentesis is conducted by one surgeon. The study also compares the clinical symptoms before and after the surgery. After the procedure, the discomfort due to xerostomia was reduced, and the symptom was improved effectively.

CONCLUSIONS

The results of this study showed that sialocentesis has a clinical effect in the treatment of xerostomia, which is a side effect of radioiodine therapy. In addition, the possibility of further clinical application of sialocentesis in the future is found.

摘要

背景

放射性碘治疗已广泛应用于甲状腺疾病患者，但10%至30%的患者可能会出现唾液分泌减少和口干症。唾液腺穿刺术是一种清除唾液导管内炎症物质并扩张导管以促进唾液分泌和排出的操作。在本研究中，从前来医院就诊的口干症患者中选取接受放射性碘治疗的甲状腺疾病患者，比较并分析唾液腺穿刺术的效果。然后，对有放射性碘治疗经历的组和无放射性碘治疗经历的组进行比较。

结果

在本研究中，我们研究了因甲状腺疾病接受放射性碘治疗且在韩国大学安岩医院接受唾液腺穿刺术的口干症患者。唾液腺穿刺术由一名外科医生进行。该研究还比较了手术前后的临床症状。术后，口干引起的不适减轻，症状得到有效改善。

结论

本研究结果表明，唾液腺穿刺术对放射性碘治疗的副作用口干症具有临床治疗效果。此外，发现了唾液腺穿刺术未来进一步临床应用的可能性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8714/6728110/5a0dc0defb00/40902_2019_223_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8714/6728110/fb347512ff3d/40902_2019_223_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8714/6728110/1dc5d5cf5357/40902_2019_223_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8714/6728110/750f7a473bb0/40902_2019_223_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8714/6728110/4999f9946903/40902_2019_223_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8714/6728110/ed2ad89d5fed/40902_2019_223_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8714/6728110/5a0dc0defb00/40902_2019_223_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8714/6728110/fb347512ff3d/40902_2019_223_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8714/6728110/1dc5d5cf5357/40902_2019_223_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8714/6728110/750f7a473bb0/40902_2019_223_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8714/6728110/4999f9946903/40902_2019_223_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8714/6728110/ed2ad89d5fed/40902_2019_223_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8714/6728110/5a0dc0defb00/40902_2019_223_Fig6_HTML.jpg

相似文献

1
Preliminary study on the efficacy of xerostomia treatment with sialocentesis targeting thyroid disease patients given radioiodine therapy.针对接受放射性碘治疗的甲状腺疾病患者，采用唾液腺穿刺术治疗口干症的疗效初步研究。
Maxillofac Plast Reconstr Surg. 2019 Sep 5;41(1):39. doi: 10.1186/s40902-019-0223-3. eCollection 2019 Dec.
2
Effects of Radioiodine Treatment on Salivary Gland Function in Patients with Differentiated Thyroid Carcinoma: A Prospective Study.放射性碘治疗对分化型甲状腺癌患者唾液腺功能的影响：一项前瞻性研究。
J Nucl Med. 2016 Nov;57(11):1685-1691. doi: 10.2967/jnumed.115.169888. Epub 2016 Jun 23.
3
Sialolithotomy of the submandibular duct using sialendoscopy.使用唾液腺内镜进行下颌下腺导管涎石切除术。
Maxillofac Plast Reconstr Surg. 2019 Jun 24;41(1):24. doi: 10.1186/s40902-019-0207-3. eCollection 2019 Dec.
4
Impact of sialendoscopy on improving health related quality of life in patients suffering from radioiodineinduced xerostomia.唾液腺内镜检查对改善放射性碘诱导的口干症患者健康相关生活质量的影响。
Nuklearmedizin. 2018 Aug;57(4):160-167. doi: 10.3413/Nukmed-0964-18-03. Epub 2018 Aug 20.
5
Salivary and lacrimal gland dysfunction (sicca syndrome) after radioiodine therapy.放射性碘治疗后的唾液腺和泪腺功能障碍（干燥综合征）。
J Nucl Med. 2001 May;42(5):738-43.
6
Salivary side effects after radioiodine treatment for differentiated papillary thyroid carcinoma: Long-term study.分化型甲状腺乳头状癌放射性碘治疗后的唾液腺副作用：长期研究
Head Neck. 2020 Nov;42(11):3133-3140. doi: 10.1002/hed.26359. Epub 2020 Jul 11.
7
Sialendoscopy for Patients with Radioiodine-Induced Sialadenitis and Xerostomia.放射性碘诱发的涎腺炎和口干症患者的唾液腺内镜检查
Thyroid. 2015 Jul;25(7):834-8. doi: 10.1089/thy.2014.0572. Epub 2015 May 15.
8
Salivary gland function after sialendoscopy for treatment of chronic radioiodine-induced sialadenitis.涎腺内镜治疗慢性放射性碘诱发涎腺炎后的涎腺功能
Head Neck. 2016 Jan;38(1):51-8. doi: 10.1002/hed.23844. Epub 2015 Jan 27.
9
Salivary gland protection by amifostine in high-dose radioiodine therapy of differentiated thyroid cancer.氨磷汀在分化型甲状腺癌高剂量放射性碘治疗中对唾液腺的保护作用。
Strahlenther Onkol. 1999 Feb;175(2):57-61. doi: 10.1007/BF02753843.
10
Radioprotection of salivary glands by amifostine in high-dose radioiodine treatment. Results of a double-blinded, placebo-controlled study in patients with differentiated thyroid cancer.氨磷汀在高剂量放射性碘治疗中对唾液腺的放射防护作用。一项针对分化型甲状腺癌患者的双盲、安慰剂对照研究的结果。
Strahlenther Onkol. 1999 Nov;175 Suppl 4:6-12.

引用本文的文献

1
Therapeutic effects of sialendoscopy for diagnosis and treatment of hyposalivation patients: a retrospective study.唾液腺内镜对唾液分泌减少患者的诊断和治疗效果：一项回顾性研究
Maxillofac Plast Reconstr Surg. 2022 Oct 24;44(1):34. doi: 10.1186/s40902-022-00360-8.

本文引用的文献

1
Sialolithotomy of the submandibular duct using sialendoscopy.使用唾液腺内镜进行下颌下腺导管涎石切除术。
Maxillofac Plast Reconstr Surg. 2019 Jun 24;41(1):24. doi: 10.1186/s40902-019-0207-3. eCollection 2019 Dec.
2
Sialendoscopy enhances salivary gland function in Sjögren's syndrome: a 6-month follow-up, randomised and controlled, single blind study.涎腺镜检查增强干燥综合征患者的唾液腺功能：一项 6 个月随访、随机对照、单盲研究。
Ann Rheum Dis. 2018 Jul;77(7):1025-1031. doi: 10.1136/annrheumdis-2017-212672. Epub 2018 Feb 23.
3
Sialendoscopy-assisted treatment for radioiodine-induced sialadenitis.
唾液腺内镜辅助治疗放射性碘诱发的涎腺炎。
J Oral Maxillofac Surg. 2015 Mar;73(3):475-81. doi: 10.1016/j.joms.2014.09.025. Epub 2014 Oct 12.
4
Sialoendoscopy: a viable treatment for I(131) induced sialoadenitis.唾液腺内镜检查：一种治疗碘-131诱导的涎腺炎的可行方法。
Br J Oral Maxillofac Surg. 2014 Sep;52(7):641-6. doi: 10.1016/j.bjoms.2014.01.025. Epub 2014 Jun 2.
5
Interventional sialendoscopy for treatment of radioiodine-induced sialadenitis.介入性涎腺内镜治疗放射性碘诱发的涎腺炎。
Laryngoscope. 2009 May;119(5):864-7. doi: 10.1002/lary.20140.
6
Sialoendoscopic treatment for radioiodine induced sialadenitis.涎腺内镜治疗放射性碘诱发的涎腺炎。
Laryngoscope. 2007 Jan;117(1):133-6. doi: 10.1097/01.mlg.0000247776.72484.62.
7
Radiation parotitis from radioactive iodine therapy.
Proc Staff Meet Mayo Clin. 1955 Apr 20;30(8):149-53.
8
Radioactive iodine and the salivary glands.放射性碘与唾液腺
Thyroid. 2003 Mar;13(3):265-71. doi: 10.1089/105072503321582060.
9
Salivary and lacrimal gland dysfunction (sicca syndrome) after radioiodine therapy.放射性碘治疗后的唾液腺和泪腺功能障碍（干燥综合征）。
J Nucl Med. 2001 May;42(5):738-43.
10
Salivary gland scanning with technetium 99m pertechnetate.
Am J Roentgenol Radium Ther Nucl Med. 1968 Jan;102(1):109-16. doi: 10.2214/ajr.102.1.109.