Kim Young-Mo, Choi Jeong-Seok, Hong Seong Bin, Hyun In Young, Lim Jae-Yol
Department of Otorhinolaryngology - Head and Neck Surgery, Inha University School of Medicine, Incheon, Republic of Korea.
Department of Internal Medicine, Inha University School of Medicine, Incheon, Republic of Korea.
Head Neck. 2016 Jan;38(1):51-8. doi: 10.1002/hed.23844. Epub 2015 Jan 27.
The purpose of this study was to determine whether sialendoscopy could ameliorate radioactive iodine-induced obstructive sialadenitis and restore the salivary gland dysfunction in recalcitrant radioactive iodine sialadenitis.
Ten patients with 15 parotid glands of chronic radioactive iodine sialadenitis who did not respond to medical treatment were enrolled in this prospective study. We assessed subjective symptom scores and evaluated the objective salivary gland functions before and 3 months after sialendoscopy.
The post-sialendoscopic obstructive symptoms were significantly improved relative to pre-sialendoscopy (p = .009). Xerostomia-related symptom scores post-sialendoscopy did not differ significantly from the pre-sialendoscopy scores. Stimulated salivary flow rate post-sialendoscopy tended to increase relative to pre-sialendoscopy. No pre-sialendoscopic parameters associated with salivary uptake and secretion by salivary gland scintigraphy were significantly improved post-sialendoscopy.
These results show that sialendoscopy can improve obstructive symptoms; however, it seems to have some limitations for relief of xerostomia and improvement of salivary gland dysfunctions in recalcitrant chronic radioactive iodine sialadenitis.
本研究旨在确定唾液腺内镜检查能否改善放射性碘诱发的阻塞性涎腺炎，并恢复顽固性放射性碘涎腺炎患者的唾液腺功能障碍。
本前瞻性研究纳入了10例患有15个腮腺慢性放射性碘涎腺炎且药物治疗无效的患者。我们在唾液腺内镜检查前及检查后3个月评估了主观症状评分，并评价了唾液腺客观功能。
与唾液腺内镜检查前相比，检查后的阻塞性症状有显著改善（p = 0.009）。唾液腺内镜检查后口干相关症状评分与检查前相比无显著差异。唾液腺内镜检查后刺激唾液流速相对于检查前有增加趋势。唾液腺闪烁显像显示，唾液腺内镜检查后，与唾液摄取和分泌相关的检查前参数无显著改善。
这些结果表明，唾液腺内镜检查可改善阻塞性症状；然而，对于缓解顽固性慢性放射性碘涎腺炎患者的口干及改善唾液腺功能障碍，似乎存在一定局限性。
