Department of Bioengineering, University of California , Los Angeles , CA , USA.
Department of Urology, University of California , Los Angeles , CA , USA.
Int J Hyperthermia. 2019;36(1):993-1002. doi: 10.1080/02656736.2019.1660811.
To develop a phantom with optical and thermal properties matched to human prostate. This phantom will provide a platform for the development and characterization of 980 nm laser interstitial thermal therapy (LITT) systems. A polyacrylamide gel was doped with Naphthol Green B, Intralipid, and Bovine Serum Albumin (BSA). The necessary concentration of each ingredient was determined by measuring the optical properties via fluence measurements and light diffusion theory. LITT was then performed under the same conditions as a previous clinical trial in which temperature was monitored via a thermal probe. The thermal data and induced coagulation zone were compared to clinical data to illustrate the similarity between the phantom and patient. LITT was also performed under magnetic resonance thermometry (MRT). The requisite concentrations of Naphthol Green B, Intralipid and BSA were found to be 0.144% (w/v), 8.06% (v/v) and 31.4% (v/v) respectively. In the native state, the absorption coefficient and reduced scattering coefficient ( ) were found to be 0.66 ± 0.06 cm and 8.27 ± 0.50 cm respectively, with increasing to 17.63 ± 1.41 cm after coagulation. The thermal response of the phantom was similar to that observed clinically with maximum thermal probe measurements of 64.2 °C and 66.9 °C respectively. The shape of the induced coagulation zone was qualitatively and quantitatively similar to the MRT zone of elevated temperature and the coagulation zone observed clinically. A phantom which simulates optical and thermal response to 980 nm LITT was constructed and demonstrated to be similar to human prostate.
为开发一种具有与人前列腺光学和热性能相匹配的特性的体模。该体模将为 980nm 激光间质热疗（LITT）系统的开发和特性描述提供一个平台。聚丙酰胺凝胶中掺杂了萘酚绿 B、Intralipid 和牛血清白蛋白（BSA）。通过测量光密度和光扩散理论，确定了每种成分的必要浓度。在与之前临床试验相同的条件下进行了 LITT，其中通过热探头监测温度。将热数据和诱导的凝固区与临床数据进行了比较，以说明体模与患者之间的相似性。还在磁共振测温（MRT）下进行了 LITT。发现萘酚绿 B、Intralipid 和 BSA 的必要浓度分别为 0.144%（w/v）、8.06%（v/v）和 31.4%（v/v）。在自然状态下，吸收系数和降低散射系数（ ）分别为 0.66±0.06cm 和 8.27±0.50cm， 增加到 17.63±1.41cm 后凝固。体模的热响应与临床观察到的相似，最大热探头测量值分别为 64.2°C 和 66.9°C。诱导的凝固区的形状在定性和定量上都与升高温度的 MRT 区和临床上观察到的凝固区相似。构建了一种模拟 980nm LITT 的光学和热响应的体模，并证明其与人前列腺相似。
