Ignelzi R J, Nyquist J K
J Neurosurg. 1979 Dec;51(6):824-33. doi: 10.3171/jns.1979.51.6.0824.
The Melzack-Wall gate control theory has been invoked to explain the peripheral analgesia resulting from repetitive electrical stimulation of peripheral nerve. This model emphasizes presynaptic inhibitory interactions among afferent fiber terminals in the spinal cord. An alternative explanation, that of velocity change in peripheral nerve fiber conduction, has been suggested by compound action potential studies from our laboratory. The present study was designed to extend this work, and to investigate the single fiber changes subsequent to brief (5- to 20-minute) periods of repetitive, high frequency (180 to 200/sec) electrical stimulation through an implantable peripheral nerve cuff device of the type used clinically for pain relief. Most fibers, regardless of their diameter (estimated from conduction velocity), show one or more of the following characteristics: a transient slowing of conduction velocity, an increase in electrical threshold and/or a decrease in response probability following a period of repetitive electrical stimulation. This supports the hypothesis that there are changes in direct peripheral nerve fiber excitability occurring under conditions simulating clinical electroanalgesia.
梅尔扎克 - 沃尔闸门控制理论已被用于解释外周神经重复电刺激所产生的外周镇痛作用。该模型强调脊髓中传入纤维终末之间的突触前抑制性相互作用。我们实验室的复合动作电位研究提出了另一种解释，即外周神经纤维传导速度的变化。本研究旨在扩展这项工作，并通过临床上用于缓解疼痛的可植入外周神经袖套装置，研究在短暂（5至20分钟）的重复高频（180至200次/秒）电刺激后单纤维的变化。大多数纤维，无论其直径（根据传导速度估计）如何，在重复电刺激一段时间后，都表现出以下一种或多种特征：传导速度短暂减慢、电阈值升高和/或反应概率降低。这支持了这样一种假设，即在模拟临床电镇痛的条件下，外周神经纤维的直接兴奋性会发生变化。
