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微小染色体维持蛋白 mRNA 表达在人肺腺癌中的预后意义。

Prognostic significance of minichromosome maintenance mRNA expression in human lung adenocarcinoma.

机构信息

Department of Hematology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China.

Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China.

出版信息

Oncol Rep. 2019 Dec;42(6):2279-2292. doi: 10.3892/or.2019.7330. Epub 2019 Sep 23.

DOI:10.3892/or.2019.7330
PMID:31545501
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6826304/
Abstract

The minichromosome maintenance (MCM) gene family plays an essential role in DNA replication and cell cycle progression. However, MCM gene expression has not been well‑studied in lung adenocarcinoma (LUAD). In the present study, the expression, prognostic value and functions of MCMs in LUAD were investigated using several databases and bioinformatic tools, including Oncomine, GEPIA, cBioPortal, CancerSEA and Kaplan‑Meier plotter. It was demonstrated that the mRNA expression of MCM2, MCM4 and MCM10 were significantly increased in patients with LUAD. High mRNA expression of MCM2‑5, MCM8 and MCM10 were associated with poor overall survival and progression‑free survival. High MCM4 expression was associated with adverse post‑progression survival. In addition, the Human Protein Atlas database showed that MCM protein expression was consistent with the mRNA expression. These results demonstrate that MCM2, MCM4 and MCM10 are potential prognostic markers and therapeutic targets for LUAD.

摘要

微小染色体维持 (MCM) 基因家族在 DNA 复制和细胞周期进程中发挥着重要作用。然而，MCM 基因在肺腺癌 (LUAD) 中的表达尚未得到充分研究。本研究利用 Oncomine、GEPIA、cBioPortal、CancerSEA 和 Kaplan-Meier plotter 等多个数据库和生物信息学工具，研究了 MCM 在 LUAD 中的表达、预后价值和功能。结果表明，MCM2、MCM4 和 MCM10 的 mRNA 表达在 LUAD 患者中显著增加。MCM2-5、MCM8 和 MCM10 的高 mRNA 表达与总生存期和无进展生存期不良相关。高 MCM4 表达与不良的后进展生存期相关。此外，人类蛋白质图谱数据库表明 MCM 蛋白表达与 mRNA 表达一致。这些结果表明，MCM2、MCM4 和 MCM10 可能是 LUAD 的潜在预后标志物和治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc1f/6826304/8e5da14f8bb0/or-42-06-2279-g12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc1f/6826304/9d7e4c9ed5bc/or-42-06-2279-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc1f/6826304/bdacbe82f67b/or-42-06-2279-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc1f/6826304/d28d4087f864/or-42-06-2279-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc1f/6826304/afd1336670a2/or-42-06-2279-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc1f/6826304/d7d1337779ae/or-42-06-2279-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc1f/6826304/35dd03e710d9/or-42-06-2279-g07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc1f/6826304/ab2c13e70271/or-42-06-2279-g09.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc1f/6826304/b34f65e0b206/or-42-06-2279-g11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc1f/6826304/8e5da14f8bb0/or-42-06-2279-g12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc1f/6826304/9d7e4c9ed5bc/or-42-06-2279-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc1f/6826304/bdacbe82f67b/or-42-06-2279-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc1f/6826304/d28d4087f864/or-42-06-2279-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc1f/6826304/afd1336670a2/or-42-06-2279-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc1f/6826304/d7d1337779ae/or-42-06-2279-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc1f/6826304/35dd03e710d9/or-42-06-2279-g07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc1f/6826304/ab2c13e70271/or-42-06-2279-g09.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc1f/6826304/b34f65e0b206/or-42-06-2279-g11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc1f/6826304/8e5da14f8bb0/or-42-06-2279-g12.jpg

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