Gonnering R S, Sonneland P R
Department of Ophthalmology, University of Wisconsin Medical School, Madison.
Ophthalmic Plast Reconstr Surg. 1987;3(1):29-33. doi: 10.1097/00002341-198701000-00007.
A 72-year-old man had secondary orbital involvement with dermatofibrosarcoma protuberans 36 years after removal of the initial tumor on his forehead. In addition, multiple bilateral inferior orbital masses were present, which on pathologic examination proved to be reactive lymphoid hyperplasia. Serum immunoelectrophoresis revealed polyclonal elevations of IgG and IgA. Dermatofibrosarcoma protuberans is part of the spectrum of fibrohistiocytic tumors that also includes atypical fibroxanthoma and benign and malignant fibrous histiocytoma. The exact cell of origin of dermatofibrosarcoma protuberans is controversial, though immunohistochemical study of our specimen supports the fibroblast. The coexistence of this rare orbital tumor with noncontiguous reactive lymphoid hyperplasia is unique, and points out the fact that multiple orbital masses may indicate more than one underlying disease process.
一名72岁男性在其前额的原发性肿瘤切除36年后，出现了隆突性皮肤纤维肉瘤的继发性眼眶受累。此外，双侧眼眶下部有多个肿块，病理检查证实为反应性淋巴样增生。血清免疫电泳显示IgG和IgA多克隆升高。隆突性皮肤纤维肉瘤是纤维组织细胞肿瘤谱系的一部分，该谱系还包括非典型纤维性黄色瘤以及良性和恶性纤维组织细胞瘤。尽管对我们标本的免疫组织化学研究支持其起源于成纤维细胞，但隆突性皮肤纤维肉瘤的确切起源细胞仍存在争议。这种罕见的眼眶肿瘤与不连续的反应性淋巴样增生并存是独特的，这也指出了多个眼眶肿块可能提示不止一种潜在疾病过程这一事实。
