非编码 RNA 在食管鳞状细胞癌中的新兴作用。
Emerging Role of Non-Coding RNAs in Esophageal Squamous Cell Carcinoma.
机构信息
State Key Laboratory of Chemical Resource Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
Key Laboratory of Molecular Pathology, School of Basic Medical Science, Inner Mongolia Medical University, Hohhot 010110, China.
出版信息
Int J Mol Sci. 2019 Dec 30;21(1):258. doi: 10.3390/ijms21010258.
Esophageal squamous cell carcinoma (ESCC) is a highly prevalent tumor and is associated with ethnicity, genetics, and dietary intake. Non-coding RNAs (ncRNAs), specifically microRNAs (miRNAs), long ncRNAs (lncRNAs), and circular RNAs (circRNAs) have been reported as functional regulatory molecules involved in the development of many human cancers, including ESCC. Recently, several ncRNAs have been detected as oncogenes or tumor suppressors in ESCC progression. These ncRNAs influence the expression of specific genes or their associated signaling pathways. Moreover, interactions of ncRNAs are evident in ESCC, as miRNAs regulate the expression of lncRNAs, and further, lncRNAs and circRNAs function as miRNA sponges to compete with the endogenous RNAs. Here, we discuss and summarize the findings of recent investigations into the role of ncRNAs (miRNAs, lncRNAs, and circRNAs) in the development and progression of ESCC and how their interactions regulate ESCC development.
食管鳞状细胞癌（ESCC）是一种高发肿瘤，与种族、遗传和饮食摄入有关。非编码 RNA（ncRNA），特别是 microRNAs（miRNAs）、长链非编码 RNA（lncRNAs）和环状 RNA（circRNAs），已被报道为参与多种人类癌症发展的功能调节分子，包括 ESCC。最近，一些 ncRNA 被检测为 ESCC 进展中的癌基因或肿瘤抑制因子。这些 ncRNA 影响特定基因的表达或其相关信号通路。此外，ncRNA 的相互作用在 ESCC 中很明显，因为 miRNAs 调节 lncRNA 的表达，而 lncRNA 和 circRNA 作为 miRNA 海绵发挥作用，与内源性 RNA 竞争。在这里，我们讨论并总结了最近关于 ncRNA（miRNAs、lncRNAs 和 circRNAs）在 ESCC 发生和发展中的作用的研究结果，以及它们的相互作用如何调节 ESCC 的发展。
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