Huh K B, Park H S, Kim H M, Lim S K, Kim K R, Lee H C
Korean J Intern Med. 1986 Jul;1(2):198-204. doi: 10.3904/kjim.1986.1.2.198.
Diet and exercise could be an essential part of the treatment of non-insulin dependent diabetes mellitus (NIDDM). The effects of a strict dietary restriction (800–1,200 Kcal/day) with exercise (2-hour walk per day) on glycemic control were evaluatedin NIDDM patients. A short-term study was performed on 147 cases In these cases, the duration of hospitalization was 7–14 days. We achieved glycemic control [fasting blood sugar (FBS) less than 140 mg/dl] in 112 cases (76%). Among them, 78 (53%) were controlled with diet and exercise only and in 34 (23%), control was induced with oral gliquidone treatment for about 5 days A long-term study was done on 76 cases who followed our program for from 1 to 12 months (mean : 3.8 months) after discharge. Glycemic control was maintained in 56 (74%) in spite of the insignificance of the amount of weight reduction. Glycemic control was significantly related to the duration of diabetes, diabetic complications and the peak C-peptide level, but was unrelated to the initial body weight, FBS levels and HbA levels. These data indicate that a program of diet and exercise must be an integral part in the treatment of NIDDM. This was true, especially, for patients who have had adequate insulin secretory capacity few diabetic complications, short duration of disease, and no previous history of oral hypoglycemic agents or insulin therapy.
饮食和运动可能是非胰岛素依赖型糖尿病（NIDDM）治疗的重要组成部分。我们评估了严格饮食限制（800 - 1200千卡/天）并结合运动（每天步行2小时）对NIDDM患者血糖控制的影响。对147例患者进行了一项短期研究，这些患者的住院时间为7 - 14天。我们使112例患者（76%）实现了血糖控制[空腹血糖（FBS）低于140毫克/分升]。其中，78例（53%）仅通过饮食和运动得到控制，34例（23%）通过口服格列喹酮治疗约5天实现了控制。对76例患者进行了一项长期研究，这些患者出院后遵循我们的方案1至12个月（平均：3.8个月）。尽管体重减轻量不显著，但56例（74%）患者的血糖控制得以维持。血糖控制与糖尿病病程、糖尿病并发症及C肽峰值水平显著相关，但与初始体重、FBS水平和糖化血红蛋白（HbA）水平无关。这些数据表明，饮食和运动方案必须是NIDDM治疗中不可或缺的一部分。对于胰岛素分泌能力充足、糖尿病并发症少、病程短且既往无口服降糖药或胰岛素治疗史的患者尤其如此。
