与青蛙横纹肌内向整流钾通道串联的电压依赖性门控通道。
A voltage-dependent gate in series with the inwardly rectifying potassium channel in frog striated muscle.
作者信息
Mancinelli E, Peres A
出版信息
J Physiol. 1979 Aug;293:301-18. doi: 10.1113/jphysiol.1979.sp012890.
Abstract
- The degree of tubular potassium depletion and the decrease of potassium conductance due to hyperpolarizing pulses in striated muscular fibres have been examined with the three micro-electrode voltage-clamp technique. 2. The conductance of the fibre membrane has been measured in different extracellular K+ concentrations from 1 to 10 mM. 3. Comparison of the two sets of measurements shows that changes in tubular K+ concentration are not sufficient to account for the conductance decrease associated with hyperpolarization. 4. The presence of a voltage-dependent gate in series with the inwardly rectifying channel for K+ ions, suggested by Almers (1972a, b), is thus confirmed.
摘要
- 运用三微电极电压钳技术，研究了横纹肌纤维中管状钾离子缺失的程度以及超极化脉冲导致的钾离子电导率降低情况。2. 在1至10 mM的不同细胞外钾离子浓度下测量了纤维膜的电导率。3. 两组测量结果的比较表明，管状钾离子浓度的变化不足以解释与超极化相关的电导率降低。4. 由此证实了阿尔默斯（1972a，b）提出的存在与钾离子内向整流通道串联的电压依赖性门控。
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本文引用的文献
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Voltage clamp experiments in striated muscle fibres.横纹肌纤维的电压钳实验。
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