Department of Bionanotechnology, Gachon University, San 65, Bokjeong-Dong, Sujeong-Gu, Seongnam-Si, Gyeonggi-Do 461-701, Republic of Korea.
Department of Bionanotechnology, Gachon University, San 65, Bokjeong-Dong, Sujeong-Gu, Seongnam-Si, Gyeonggi-Do 461-701, Republic of Korea.
Mater Sci Eng C Mater Biol Appl. 2019 Dec;105:110091. doi: 10.1016/j.msec.2019.110091. Epub 2019 Aug 15.
Nanostructured metal-organic frameworks (N-MOFs) are crystalline coordination nanopolymers in which metals are conjugated with organic and inorganic linker molecules. At present, N-MOFs have attracted significant interest owing to their intrinsically high porosity and ultrahigh surface areas, which allow them to be loaded with a broad array of materials, including drug molecules. In addition, N-MOFs possess other unique properties, such as good mobility, high reactivity, outstanding stability, real-time intracellular pH sensitivity, photosensitization, and penetration ability, which make them suitable candidates as drug delivery carriers for cancer and other targeted therapies. The opportunity for using a diverse array of chemical building components in N-MOFs facilitates the formation of structures with preferred properties for targeted therapy. In this review, we focus on the synthesis, characterization and other potential applications of N-MOFs in targeted theranostic nanodrug for cancer therapy.
纳米结构金属有机骨架（N-MOFs）是由金属与有机和无机连接分子共轭而成的结晶配位纳米聚合物。目前，N-MOFs 因其固有的高孔隙率和超高比表面积而引起了人们的极大兴趣，这使得它们能够负载广泛的材料，包括药物分子。此外，N-MOFs 还具有其他独特的性质，如良好的迁移率、高反应性、出色的稳定性、实时细胞内 pH 敏感性、光敏性和穿透能力，这使它们成为癌症和其他靶向治疗的药物输送载体的理想候选物。在 N-MOFs 中使用多种化学构建组件的机会促进了具有靶向治疗所需特性的结构的形成。在这篇综述中，我们重点介绍了 N-MOFs 在癌症治疗的靶向治疗纳米药物中的合成、表征和其他潜在应用。
