Kim Kibeom, Park Myoung-Hwan
Convergence Research Center, Nanobiomaterials Institute, Sahmyook University, Seoul 01795, Republic of Korea.
Department of Chemistry and Life Science, Sahmyook University, Seoul 01795, Republic of Korea.
Biomedicines. 2024 Jan 31;12(2):326. doi: 10.3390/biomedicines12020326.
Cancer remains a major global health challenge, necessitating the development of innovative treatment strategies. This review focuses on the functionalization of porous nanoparticles for combination therapy, a promising approach to enhance cancer treatment efficacy while mitigating the limitations associated with conventional methods. Combination therapy, integrating multiple treatment modalities such as chemotherapy, phototherapy, immunotherapy, and others, has emerged as an effective strategy to address the shortcomings of individual treatments. The unique properties of mesoporous silica nanoparticles (MSN) and other porous materials, like nanoparticles coated with mesoporous silica (NP@MS), metal-organic frameworks (MOF), mesoporous platinum nanoparticles (mesoPt), and carbon dots (CDs), are being explored for drug solubility, bioavailability, targeted delivery, and controlled drug release. Recent advancements in the functionalization of mesoporous nanoparticles with ligands, biomaterials, and polymers are reviewed here, highlighting their role in enhancing the efficacy of combination therapy. Various research has demonstrated the effectiveness of these nanoparticles in co-delivering drugs and photosensitizers, achieving targeted delivery, and responding to multiple stimuli for controlled drug release. This review introduces the synthesis and functionalization methods of these porous nanoparticles, along with their applications in combination therapy.
癌症仍然是一项重大的全球健康挑战，因此有必要开发创新的治疗策略。本综述聚焦于用于联合治疗的多孔纳米颗粒的功能化，这是一种很有前景的方法，可提高癌症治疗效果，同时减轻传统方法的局限性。联合治疗整合了多种治疗方式，如化疗、光疗、免疫疗法等，已成为一种应对单一治疗缺点的有效策略。介孔二氧化硅纳米颗粒（MSN）和其他多孔材料的独特性质，如介孔二氧化硅包覆的纳米颗粒（NP@MS）、金属有机框架（MOF）、介孔铂纳米颗粒（mesoPt）和碳点（CDs），正被用于探索药物溶解性、生物利用度、靶向递送和药物控释。本文综述了用配体、生物材料和聚合物对介孔纳米颗粒进行功能化的最新进展，强调了它们在提高联合治疗效果中的作用。各种研究已证明这些纳米颗粒在共同递送药物和光敏剂、实现靶向递送以及对多种刺激做出响应以实现药物控释方面的有效性。本综述介绍了这些多孔纳米颗粒的合成和功能化方法，以及它们在联合治疗中的应用。
