Institute of Chemical Technology and Engineering, Poznan University of Technology, Berdychowo 4, 60-965 Poznań, Poland.
Institute of Physics, Poznan University of Technology, Piotrowo 3, 60-965 Poznań, Poland.
Mater Sci Eng C Mater Biol Appl. 2019 Dec;105:110090. doi: 10.1016/j.msec.2019.110090. Epub 2019 Aug 15.
Functionalized polyhedral oligomeric silsesquioxanes (POSS) derivatives have great potential in biomedical applications such as tissue engineering, drug delivery, biosensors, dental composites and biomedical devices. Having the above in mind, in this paper, the study of the surface characteristics of binary Langmuir-Blodgett films consisting of an open cage silsesquioxane POSS-poly (ethylene glycol) (POSS-PEG) and 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine (DMPE), as a representative of phospholipid was conducted based on contact angle measurements of three liquids. The measured values of the contact angle (with water, formamide and diiodomethane as the wetting liquids) allowed to calculate surface free energy of the films from van Oss et al. approach. The film structure of the deposited layers was evaluated using an atomic force microscope. Analysis of the obtained results led to the conclusion, that the pure DMPE molecules create agglomerates onto a solid substrate, whereas the POSS-PEG molecules form a homogenous monolayer. After an addition of POSS-PEG to lipid film, changes in the surface properties are visible. The wettability as well as surface free energy depend on the molar ratio of both components. The AFM images shed more light on the changes of the DMPE monolayer topography caused by the POSS-PEG addition.
功能化多面体低聚倍半硅氧烷（POSS）衍生物在生物医学应用中有很大的潜力，如组织工程、药物输送、生物传感器、牙科复合材料和生物医学设备。考虑到这一点，在本文中，我们研究了由笼型 POSS-聚（乙二醇）（POSS-PEG）和 1,2-二月桂酰基-sn-甘油-3-磷酸乙醇胺（DMPE）组成的二元 Langmuir-Blodgett 薄膜的表面特性，DMPE 是磷脂的代表。基于三种液体的接触角测量，对薄膜进行了研究。通过 van Oss 等人的方法，从接触角的测量值（以水、甲酰胺和二碘甲烷作为润湿液体）计算了薄膜的表面自由能。使用原子力显微镜评估了沉积层的薄膜结构。对获得的结果进行分析后得出结论，即纯 DMPE 分子在固体基底上形成聚集体，而 POSS-PEG 分子形成均匀的单分子层。在向脂质膜中添加 POSS-PEG 后，表面性质发生了变化。润湿性和表面自由能取决于两种成分的摩尔比。原子力显微镜图像更清楚地显示了 POSS-PEG 加入引起的 DMPE 单层形貌的变化。
