Department of Food and Nutrition, Providence University, Shalu Dist., Taichung 43301, Taiwan.
Division of Allergy, Immunology & Rheumatology, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Tanzi Dist., Taichung 42743, Taiwan.
Nutrients. 2019 Sep 19;11(9):2256. doi: 10.3390/nu11092256.
is a rare and valuable medicinal mushroom indigenous to Taiwan. It has traditionally been used to promote good health. This study aimed to explore the immunomodulatory effects of "Leader Deluxe capsule" (LDAC). LDAC is a healthy food product composed of fruiting body extract and solid-state-cultivated mycelia of . Two complementary studies were performed. In the first, LDAC was orally administered to BABL/c female mice for 6 weeks as part of a non-specific immune study. In the second, mice were treated with LDAC for 8 weeks and immunized with ovalbumin (OVA) in a specific immune study. LDAC increased the growth of splenic immune cells and enhanced the activity of macrophages and natural killer cells. It increased the levels of interleukin (IL)-2, interferon (IFN)-γ, serum immunoglobulin (Ig)G, and OVA-IgG, and decreased the levels of IL-4, IL-5, tumor necrosis factor (TNF)-α, serum IgE, and OVA-IgE. Thus, the findings of this study strongly supported the idea that LDAC possesses immunomodulatory activity.
是一种珍稀且珍贵的药用蘑菇，原产于中国台湾。它一直被用于促进身体健康。本研究旨在探索“领袖特级胶囊”（LDAC）的免疫调节作用。LDAC 是一种健康食品，由子实体提取物和固态培养的菌丝体组成。进行了两项互补研究。在第一项研究中，将 LDAC 口服给予 BABL/c 雌性小鼠 6 周，作为非特异性免疫研究的一部分。在第二项研究中，将 LDAC 治疗 8 周，并在特异性免疫研究中用卵清蛋白（OVA）免疫小鼠。LDAC 增加了脾脏免疫细胞的生长，并增强了巨噬细胞和自然杀伤细胞的活性。它增加了白细胞介素（IL）-2、干扰素（IFN）-γ、血清免疫球蛋白（Ig）G 和 OVA-IgG 的水平，并降低了白细胞介素（IL）-4、IL-5、肿瘤坏死因子（TNF）-α、血清 IgE 和 OVA-IgE 的水平。因此，本研究的结果强烈支持 LDAC 具有免疫调节活性的观点。
