Carbapenemase Genes and Multidrug Resistance of : A Cross Sectional Study of Patients with Pneumonia in Southern Vietnam.

is an opportunistic bacterial pathogen found in hospital-acquired infections including nosocomial pneumonia, especially multidrug-resistant . This study aims to survey the drug resistance profiles of isolated from patients in Thong Nhat Dong Nai General Hospital and assess the relationship between genotypes and antibiotic resistance; Methods: Ninety-seven strains isolated from 340 lower respiratory tract specimens among pneumonia patients were used to screen the most common local carbapenemase genes. Antimicrobial susceptibility testing results and demographic data were collected and minimum inhibitory concentrations (MIC) of colistin were also determined; Results: Over 80% and 90% of strains were determined as carbapenem-resistant and multidrug-resistant (MDR) respectively. Most of the strains carried carbapenemase genes, including OXA-51, OXA-23-like, OXA-58-like, and NDM-1, with proportions of 97 (100%), 76 (78.4%), 10 (10.3%), 6 (6.2%), respectively. Amongst these genes, OXA-23-like was the only gene which significantly influenced the resistance ( < 0.0001); and Conclusions: The severity of antibiotic resistance is urgent and specifically related to carbapenemase encoding genes. Therefore, screening of MDR and carbapenemase for better treatment options is necessary.