Hoang Quoc Cuong, Nguyen Thi Phuong Thao, Nguyen Duc Hai, Tran Le Trung, Tran Thi Thu Hang, Nguyen Tuan Si, Phan Trong Lan
The Pasteur Institute, Ho Chi Minh City 700000, Vietnam.
Department of health and applied science, Dong Nai Technology University, Dong Nai Province 710000, Vietnam.
Antibiotics (Basel). 2019 Sep 12;8(3):148. doi: 10.3390/antibiotics8030148.
is an opportunistic bacterial pathogen found in hospital-acquired infections including nosocomial pneumonia, especially multidrug-resistant . This study aims to survey the drug resistance profiles of isolated from patients in Thong Nhat Dong Nai General Hospital and assess the relationship between genotypes and antibiotic resistance; Methods: Ninety-seven strains isolated from 340 lower respiratory tract specimens among pneumonia patients were used to screen the most common local carbapenemase genes. Antimicrobial susceptibility testing results and demographic data were collected and minimum inhibitory concentrations (MIC) of colistin were also determined; Results: Over 80% and 90% of strains were determined as carbapenem-resistant and multidrug-resistant (MDR) respectively. Most of the strains carried carbapenemase genes, including OXA-51, OXA-23-like, OXA-58-like, and NDM-1, with proportions of 97 (100%), 76 (78.4%), 10 (10.3%), 6 (6.2%), respectively. Amongst these genes, OXA-23-like was the only gene which significantly influenced the resistance ( < 0.0001); and Conclusions: The severity of antibiotic resistance is urgent and specifically related to carbapenemase encoding genes. Therefore, screening of MDR and carbapenemase for better treatment options is necessary.
是一种在医院获得性感染中发现的机会性细菌病原体，包括医院获得性肺炎，尤其是多重耐药菌。本研究旨在调查从同奈省通奈综合医院患者中分离出的该菌的耐药谱，并评估基因型与抗生素耐药性之间的关系；方法：从340例肺炎患者的下呼吸道标本中分离出97株该菌，用于筛选最常见的本地碳青霉烯酶基因。收集抗菌药物敏感性测试结果和人口统计学数据，并测定黏菌素的最低抑菌浓度（MIC）；结果：分别有超过80%和90%的该菌被确定为耐碳青霉烯类和多重耐药（MDR）。大多数菌株携带碳青霉烯酶基因，包括OXA-51、OXA-23样、OXA-58样和NDM-1，比例分别为97（100%）、76（78.4%）、10（10.3%）、6（6.2%）。在这些基因中，OXA-23样是唯一显著影响耐药性的基因（P<0.0001）；结论：该菌抗生素耐药性的严重性亟待解决，且与碳青霉烯酶编码基因密切相关。因此，筛选多重耐药菌和碳青霉烯酶以获得更好的治疗方案是必要的。
