Rangel Karyne, De-Simone Salvatore Giovanni
Center for Technological Development in Health (CDTS)/National Institute of Science and Technology for Innovation in Neglected Population Diseases (INCT-IDPN), Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, RJ, 21040-900, Brazil.
Epidemiology and Molecular Systematics Laboratory (LEMS), Oswaldo Cruz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, RJ, 21040-900, Brazil.
Infect Drug Resist. 2024 Feb 8;17:507-529. doi: 10.2147/IDR.S431525. eCollection 2024.
pneumonia is a significant healthcare-associated infection that poses a considerable challenge to clinicians due to its multidrug-resistant nature. Recent world events, such as the COVID-19 pandemic, have highlighted the need for effective treatment and management strategies for Acinetobacter pneumonia. In this review, we discuss lessons learned from recent world events, particularly the COVID-19 pandemic, in the context of the treatment and management of pneumonia. We performed an extensive literature review to uncover studies and information pertinent to the topic. The COVID-19 pandemic underscored the importance of infection control measures in healthcare settings, including proper hand hygiene, isolation protocols, and personal protective equipment use, to prevent the spread of multidrug-resistant pathogens like . Additionally, the pandemic highlighted the crucial role of antimicrobial stewardship programs in optimizing antibiotic use and curbing the emergence of resistance. Advances in diagnostic techniques, such as rapid molecular testing, have also proven valuable in identifying infections promptly. Furthermore, due to the limited availability of antibiotics for treating infections caused , alternative strategies are needed like the use of antimicrobial peptides, bacteriophages and their enzymes, nanoparticles, photodynamic and chelate therapy. Recent world events, particularly the COVID-19 pandemic, have provided valuable insights into the treatment and management of pneumonia. These lessons emphasize the significance of infection control, antimicrobial stewardship, and early diagnostics in combating this challenging infection.
肺炎是一种与医疗保健相关的重要感染，因其多重耐药性给临床医生带来了巨大挑战。近期的世界事件，如新冠疫情，凸显了对不动杆菌肺炎采取有效治疗和管理策略的必要性。在本综述中，我们将在肺炎治疗和管理的背景下，探讨从近期世界事件，特别是新冠疫情中学到的经验教训。我们进行了广泛的文献综述，以发掘与该主题相关的研究和信息。新冠疫情强调了医疗机构感染控制措施的重要性，包括正确的手部卫生、隔离规程和个人防护装备的使用，以防止像……这样的多重耐药病原体的传播。此外，疫情凸显了抗菌药物管理计划在优化抗生素使用和遏制耐药性出现方面的关键作用。诊断技术的进步，如快速分子检测，在及时识别……感染方面也已证明具有价值。此外，由于用于治疗由……引起的感染的抗生素供应有限，需要替代策略，如使用抗菌肽、噬菌体及其酶、纳米颗粒、光动力和螯合疗法。近期的世界事件，特别是新冠疫情，为不动杆菌肺炎的治疗和管理提供了宝贵的见解。这些经验教训强调了感染控制、抗菌药物管理和早期诊断在对抗这种具有挑战性的感染中的重要性。
