Cui Yu, Cui Xiang-Yan, Wu Yu, Yin Wan-Zhong, Zhu Zhan-Peng
Department of Otolaryngology, Head and Neck Surgery, First Hospital of Jilin University, Changchun, Jilin Province, China.
Department of Neurosurgery, First Hospital of Jilin University, Changchun, Jilin Province, China.
J Int Med Res. 2019 Nov;47(11):5824-5830. doi: 10.1177/0300060519865645. Epub 2019 Sep 23.
Small cell lung cancer metastasizing to the parotid gland is very rare and only a few cases have been reported. A 64-year-old man presented with a painless mass and peripheral facial paralysis. Neck ultrasound identified a solid mass in the right parotid gland with enlargement of the lymph nodes in the gland and the right submandibular lymph nodes. Lung computed tomography imaging demonstrated abnormalities in the upper and middle lobes of the right lung and intermediate bronchus, with obstructive pneumonia, as well as enlargement of the right hilar and mediastinal lymph nodes. Postoperative histopathological analysis identified small cell carcinoma in the right parotid gland with involvement of the right neck lymph nodes (one of eight). Bronchoscopy was performed and immunohistochemical analysis of the specimen demonstrated possible metastasis of small cell lung cancer to the parotid gland. From postoperative day 15, the patient started to undergo six cycles of an adjuvant chemotherapy regimen. No complications of the chemotherapy regimen were observed after three cycles. Treatment and follow-up are ongoing.
小细胞肺癌转移至腮腺极为罕见，仅有少数病例报道。一名64岁男性患者出现无痛性肿块及周围性面瘫。颈部超声检查发现右侧腮腺有一实性肿块，腮腺及右颌下淋巴结肿大。肺部计算机断层扫描成像显示右肺上叶和中叶及中间支气管有异常，伴有阻塞性肺炎，以及右肺门和纵隔淋巴结肿大。术后组织病理学分析确定右侧腮腺为小细胞癌，右侧颈部淋巴结受累（8个中的1个）。进行了支气管镜检查，对标本的免疫组织化学分析表明小细胞肺癌可能转移至腮腺。从术后第15天起，患者开始接受6个周期的辅助化疗方案。3个周期后未观察到化疗方案的并发症。治疗和随访仍在进行中。
