Institute of Pathology, Barzilai University Medical Center, Ashkelon, Israel.
Institute of Pathology, The Chaim Sheba Medical Center, Tel-Hashomer, Ramat Gan, Israel; Department of Oral Pathology & Oral Medicine, School of Dental Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Acta Histochem. 2019 Nov;121(8):151444. doi: 10.1016/j.acthis.2019.151444. Epub 2019 Sep 20.
We aimed to immunohistochemically characterize the pattern of expression of epithelial markers in rare head and neck squamous cell carcinoma (HNSCC) variants: carcinoma cuniculatum (CC) and adenosquamous carcinoma (ASC). We also present an additional variant of HNSCC with concomitant basaloid and squamous components that has overlapping morphological features with odontogenic and non-odontogenic tumors, which we termed basalo-squamous carcinoma (BSC). The selected markers included CK5/6, p40, CK19, BerEP4, p16 and SOX10. All tumors were CK5/6 and p40 positive. CK19 and BerEP4 were positive in BSC and focally in ASC but negative in CC. p16 was positive in 3 (60%) of the CCs, focally positive in ASC and negative in BSC. SOX10 was negative in all three variants. Our results highlight the plasticity of the lining epithelium revealing differential profiles of immuno-expression of the selected molecular markers, possibly reflecting their diverse histopathogenesis.
我们旨在免疫组织化学上描述罕见的头颈部鳞状细胞癌（HNSCC）变体（包括腺样囊性癌和癌珠状癌）中上皮标志物表达模式。我们还介绍了一种具有基底细胞和鳞状细胞成分的 HNSCC 变体，其具有与牙源性和非牙源性肿瘤重叠的形态特征，我们将其称为基底鳞状细胞癌（BSC）。所选标志物包括 CK5/6、p40、CK19、BerEP4、p16 和 SOX10。所有肿瘤均 CK5/6 和 p40 阳性。BSC 和局灶性 ASC 中 CK19 和 BerEP4 阳性，CC 中阴性。3 例（60%）CC 中 p16 局灶性阳性，ASC 中局灶性阳性，BSC 中阴性。三种变体中 SOX10 均为阴性。我们的结果强调了衬里上皮的可塑性，揭示了所选分子标志物的免疫表达的差异谱，可能反映了它们不同的组织发生。
