口腔颌面部腺鳞癌的生存情况及危险因素：一项基于人群的研究。

Survival and risk factors of adenosquamous carcinoma in the oral and maxillofacial region: a population-based study.

作者信息

Liu Ying, Mi Yong, Zhang Li, Jiang Tao

机构信息

Center for Esthetic Dentistry, Jinan Stomatological Hospital Jinan 250001, China.

Dental Laboratory, Jinan Stomatological Hospital Jinan 250001, China.

出版信息

Am J Transl Res. 2021 Oct 15;13(10):12071-12082. eCollection 2021.

PMID:34786144

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8581841/

Abstract

BACKGROUND

The features and prognosis of adenosquamous carcinoma (ASC) in oral and maxillofacial region have not thoroughly investigated, the purpose of this study is to describe clinicopathologic characteristics, treatment, and prognostic factors of this disease.

METHODS

The data of 276 patients diagnosed with ASC in oral and maxillofacial region between 1975 and 2016 were collected from the Surveillance, Epidemiology, and End Results (SEER) database. The prognostic factors influencing overall survival (OS) and disease-specific survival (DSS) were identified by the Kaplan-Meier analysis and Cox regression analysis. The nomograms for OS and DSS were constructed to predict the prognosis of these patients.

RESULTS

Of 276 included patients, 62.7% were male and 37.3% were female, with an average age at diagnosis of 63.5 years. The most common primary site is oral cavity (170/276), followed by salivary gland (106/276). The 3-, and 5-year OS of patients with ASC in oral and maxillofacial region were 49.0% and 38.9%, while the 3-, and 5-year DSS were 67.7%, and 60.4%, respectively. Patients who underwent surgery had longer OS (mOS: 58 m vs. 8 m) and DSS (mDSS: 193 m vs. 18 m) than those who did not. Age, AJCC-T/N/M category as well as surgery were independently associated with OS. Advanced T stage, distant metastases, and surgery were independent factors for DSS. The prognostic nomograms for OS and DSS were constructed, and the C-indexes were 0.71 (95% CI 0.66-0.76) and 0.76 (95% CI 0.67-0.85), respectively.

CONCLUSION

Surgery was the favorable prognostic factor for both OS and DSS among patients with ASC in oral and maxillofacial region.

摘要

背景

口腔颌面部腺鳞癌（ASC）的特征及预后尚未得到充分研究，本研究旨在描述该疾病的临床病理特征、治疗方法及预后因素。

方法

收集1975年至2016年间监测、流行病学和最终结果（SEER）数据库中276例诊断为口腔颌面部ASC的患者的数据。通过Kaplan-Meier分析和Cox回归分析确定影响总生存期（OS）和疾病特异性生存期（DSS）的预后因素。构建OS和DSS的列线图以预测这些患者的预后。

结果

纳入的276例患者中，62.7%为男性，37.3%为女性，诊断时的平均年龄为63.5岁。最常见的原发部位是口腔（170/276），其次是唾液腺（106/276）。口腔颌面部ASC患者的3年和5年OS分别为49.0%和38.9%，而3年和5年DSS分别为67.7%和60.4%。接受手术的患者的OS（中位OS：58个月 vs. 8个月）和DSS（中位DSS：193个月 vs. 18个月）均长于未接受手术的患者。年龄、美国癌症联合委员会（AJCC）的T/N/M分类以及手术与OS独立相关。T分期晚期、远处转移和手术是DSS的独立因素。构建了OS和DSS的预后列线图，C指数分别为0.71（95%可信区间0.66 - 0.76）和0.76（95%可信区间0.67 - 0.85）。