The University of Melbourne, Department of Medicine, Royal Melbourne Hospital, Parkville, VIC, Australia.
Australian Institute for Musculoskeletal Science (AIMSS), The University of Melbourne and Western Health, St. Albans, VIC, Australia.
Front Immunol. 2019 Sep 4;10:2055. doi: 10.3389/fimmu.2019.02055. eCollection 2019.
Pre-clinical models and clinical trials demonstrate that targeting the action of the cytokine, granulocyte macrophage-colony stimulating factor (GM-CSF), can be efficacious in inflammation/autoimmunity reinforcing the importance of understanding how GM-CSF functions; a significant GM-CSF-responding cell in this context is likely to be the monocyte. This article summarizes critically the literature on the downstream cellular pathways regulating GM-CSF interaction with monocytes (and macrophages), highlighting some contentious issues, and conclusions surrounding this biology. It also suggests future directions which could be undertaken so as to more fully understand this aspect of GM-CSF biology. Given the focus of this collection of articles on monocytes, the following discussion in general will be limited to this population or to its more mature progeny, the macrophage, even though GM-CSF biology is broader than this.
临床前模型和临床试验表明，针对细胞因子粒细胞-巨噬细胞集落刺激因子（GM-CSF）的作用进行靶向治疗，在炎症/自身免疫中可能是有效的，这进一步强调了理解 GM-CSF 功能的重要性；在这种情况下，GM-CSF 的一个重要反应细胞很可能是单核细胞。本文批判性地总结了调节 GM-CSF 与单核细胞（和巨噬细胞）相互作用的下游细胞途径的文献，强调了一些有争议的问题，并围绕这一生物学得出了一些结论。它还提出了未来可以采取的一些方向，以便更全面地了解 GM-CSF 生物学的这一方面。鉴于本系列文章集中讨论单核细胞，因此以下讨论通常将仅限于该群体或其更成熟的后代，即巨噬细胞，尽管 GM-CSF 生物学的范围更广。
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