Cardiovascular Research Institute, National University Health Systems, MD6 Centre for Translational Medicine, 14 Medical Drive, Singapore 117599, Singapore.
Genome Institute of Singapore, Genome, 60 Biopolis Street, Singapore 138672, Singapore.
Cardiovasc Res. 2020 Feb 1;116(2):269-278. doi: 10.1093/cvr/cvz227.
The combination of next-generation sequencing, advanced bioinformatics analysis, and molecular research has now established circular RNAs (circRNAs) as a heterogeneous group of non-coding RNA that is widely and abundantly expressed. CircRNAs are single-stranded RNA, covalently backspliced to form closed circular loops. Different models of back-splicing have been proposed, and mechanisms for circRNA function include sequestering microRNAs, direct interaction with proteins, regulation of transcription, and translation. Exploring the role of circRNAs in different disease settings, and understanding how they contribute to disease progression promises to provide valuable insight into potential novel therapeutic approaches. Here, we review the growing number of published research on circRNAs in the heart and cardiovascular system and summarize the circRNAs that have been implicated in disease.
下一代测序、先进的生物信息学分析和分子研究的结合，现在已经将环状 RNA（circRNAs）确立为广泛表达的异质非编码 RNA 组。circRNAs 是单链 RNA，通过共价回文拼接形成闭环。已经提出了不同的回文拼接模型，circRNA 功能的机制包括与 microRNAs 结合、与蛋白质直接相互作用、转录调控和翻译。探索 circRNAs 在不同疾病环境中的作用，并了解它们如何促进疾病进展，有望为潜在的新型治疗方法提供有价值的见解。在这里，我们回顾了越来越多发表的关于心脏和心血管系统中 circRNAs 的研究，并总结了与疾病相关的 circRNAs。
