You Qianhui, Yu Jiajing, Pan Runfang, Feng Jiaming, Guo Haidong, Liu Baonian
Department of Anatomy, School of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Noncoding RNA Res. 2024 Dec 9;11:115-130. doi: 10.1016/j.ncrna.2024.11.007. eCollection 2025 Apr.
Cardiovascular diseases (CVDs) are the primary cause of death globally. The evolution of nearly all types of CVDs is characterized by a common theme: the emergence of cardiac fibrosis. The precise mechanisms that trigger cardiac fibrosis are still not completely understood. In recent years, a type of non-coding regulatory RNA molecule known as circular RNAs (circRNAs) has been reported. These molecules are produced during back splicing and possess significant biological capabilities, such as regulating microRNA activity, serving as protein scaffolds and recruiters, competing with mRNA, forming circR-loop structures to modulate transcription, and translating polypeptides. Furthermore, circRNAs exhibit a substantial abundance, notable stability, and specificity of tissues, cells, and time, endowing them with the potential as biomarkers, therapeutic targets, and therapeutic agents. CircRNAs have garnered growing interest in the field of CVDs. Recent investigations into the involvement of circRNAs in cardiac fibrosis have yielded encouraging findings. This study aims to provide a concise overview of the existing knowledge about the regulatory roles of circRNAs in cardiac fibrosis.
心血管疾病（CVDs）是全球主要的死亡原因。几乎所有类型的心血管疾病的发展都有一个共同的特点：心脏纤维化的出现。引发心脏纤维化的确切机制仍未完全明确。近年来，一种被称为环状RNA（circRNAs）的非编码调控RNA分子被报道。这些分子是在反向剪接过程中产生的，具有重要的生物学功能，如调节微小RNA活性、作为蛋白质支架和招募者、与信使RNA竞争、形成circR环结构以调节转录以及翻译多肽。此外，circRNAs具有丰富的表达量、显著的稳定性以及组织、细胞和时间特异性，使其具有作为生物标志物、治疗靶点和治疗药物的潜力。CircRNAs在心血管疾病领域越来越受到关注。最近关于circRNAs参与心脏纤维化的研究取得了令人鼓舞的成果。本研究旨在简要概述关于circRNAs在心脏纤维化中的调控作用的现有知识。
