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Can precision medicine help achieve the goal of reducing care when the risks exceed the benefits?

作者信息

Phillips Kathryn A, Marshall Deborah A, Kurian Allison W

机构信息

UCSF Center for Translational & Policy Research on Personalized Medicine (TRANSPERS), Department of Clinical Pharmacy, University of California San Francisco, San Francisco, CA 94143, USA.

UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA 94143, USA.

出版信息

Per Med. 2019 Sep;16(5):365-367. doi: 10.2217/pme-2019-0045. Epub 2019 Sep 25.

DOI:10.2217/pme-2019-0045
PMID:31552799
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6785357/
Abstract
摘要

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本文引用的文献

1
Adjuvant Chemotherapy Guided by a 21-Gene Expression Assay in Breast Cancer.基于 21 基因表达检测的乳腺癌辅助化疗。
N Engl J Med. 2018 Jul 12;379(2):111-121. doi: 10.1056/NEJMoa1804710. Epub 2018 Jun 3.
2
Recent Trends in Chemotherapy Use and Oncologists' Treatment Recommendations for Early-Stage Breast Cancer.近期化疗应用趋势及肿瘤学家对早期乳腺癌的治疗推荐。
J Natl Cancer Inst. 2018 May 1;110(5):493-500. doi: 10.1093/jnci/djx239.
3
Association of 70-Gene Signature Assay Findings With Physicians' Treatment Guidance for Patients With Early Breast Cancer Classified as Intermediate Risk by the 21-Gene Assay.70 基因签名检测结果与 21 基因检测为中危的早期乳腺癌患者医生治疗指导的相关性。
JAMA Oncol. 2018 Jan 11;4(1):e173470. doi: 10.1001/jamaoncol.2017.3470.
4
Use of Exome Sequencing for Infants in Intensive Care Units: Ascertainment of Severe Single-Gene Disorders and Effect on Medical Management.在重症监护病房对婴儿使用外显子组测序：严重单基因疾病的确诊及对医疗管理的影响
JAMA Pediatr. 2017 Dec 4;171(12):e173438. doi: 10.1001/jamapediatrics.2017.3438.
5
How do women trade-off benefits and risks in chemotherapy treatment decisions based on gene expression profiling for early-stage breast cancer? A discrete choice experiment.基于早期乳腺癌基因表达谱的化疗治疗决策中，女性如何权衡收益与风险？一项离散选择实验。
BMJ Open. 2016 Jun 2;6(6):e010981. doi: 10.1136/bmjopen-2015-010981.
6
Most Americans Do Not Believe That There Is An Association Between Health Care Prices And Quality Of Care.大多数美国人不相信医疗保健价格与医疗质量之间存在关联。
Health Aff (Millwood). 2016 Apr;35(4):647-53. doi: 10.1377/hlthaff.2015.1334.
7
Consumer familiarity, perspectives and expected value of personalized medicine with a focus on applications in oncology.消费者对个性化医疗的熟悉程度、看法及预期价值，重点关注肿瘤学中的应用。
Per Med. 2015 Jan 1;12(1):13-22. doi: 10.2217/pme.14.74.
8
Access to personalized medicine: factors influencing the use and value of gene expression profiling in breast cancer treatment.个体化医学的应用：影响乳腺癌治疗中基因表达谱应用和价值的因素。
Curr Oncol. 2014 Jun;21(3):e426-33. doi: 10.3747/co.21.1782.
9
Is there a kink in consumers' threshold value for cost-effectiveness in health care?消费者在医疗保健方面对成本效益的阈值是否存在拐点？
Health Econ. 2002 Mar;11(2):175-80. doi: 10.1002/hec.655.