Cazacu Irina M, Luzuriaga Chavez Adriana A, Mendoza Tito R, Qiao Wei, Singh Ben S, Bokhari Raza H, Saftoiu Adrian, Lee Jeffrey H, Weston Brian, Stroehlein John R, Kim Michael P, G Katz Matthew H, Maitra Anirban, McAllister Florencia, Bhutani Manoop S
Department of Gastroenterology, Hepatology and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Gastroenterology, Research Center of Gastroenterology and Hepatology, University of Medicine and Pharmacy of Craiova, Craiova, Romania.
Department of Gastroenterology, Hepatology and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Endosc Ultrasound. 2020 Jan-Feb;9(1):53-58. doi: 10.4103/eus.eus_56_19.
The current knowledge about the psychological impact of pancreatic cancer (PC) screening is limited. We aimed to assess the changes in quality of life (QOL) and level of distress after undergoing EUS in individuals with pancreatic cystic lesions (PCLs) and in patients at high risk for PC based on genetic and familial factors.
Eighty patients with PCL and/or increased genetic or familial risk for PC who had undergone EUS were contacted. Fifty percent of those patients successfully completed the brief profile of mood states (POMS) and the linear analog scale assessment (LASA) QOL questionnaires to evaluate their pre/post-EUS overall QOL. The effect size (ES) method was used to assess clinically meaningful changes in the scores.
There was a significant difference in patients' overall QOL scores before and after the EUS procedure (LASA, mean difference 0.73, standard deviation (SD) 1.76, ES 0.58, P < 0.01; brief POMS, mean difference -5.46, SD -6.72, ES 0.81, P < 0.01).
QOL of patients with PCL or increased risk factors for PC is significantly improved after a EUS/EUS-guided fine-needle aspiration (FNA) negative for malignancy.
目前关于胰腺癌（PC）筛查对心理影响的认识有限。我们旨在评估胰腺囊性病变（PCL）患者以及基于遗传和家族因素处于PC高风险的患者在接受超声内镜检查（EUS）后生活质量（QOL）的变化和痛苦程度。
联系了80例接受过EUS检查的PCL患者和/或PC遗传或家族风险增加的患者。其中50%的患者成功完成了情绪状态简表（POMS）和线性模拟量表评估（LASA）QOL问卷，以评估他们EUS前后的总体QOL。效应量（ES）方法用于评估分数的临床意义变化。
EUS检查前后患者的总体QOL评分存在显著差异（LASA，平均差异0.73，标准差（SD）1.76，ES 0.58，P<0.01；POMS简表，平均差异-5.46，SD -6.72，ES 0.81，P<0.01）。
对于恶性肿瘤EUS/EUS引导下细针穿刺活检（FNA）结果为阴性的PCL患者或PC风险因素增加的患者，其QOL显著改善。
