加速、高剂量θ爆发刺激是否是治疗抵抗性抑郁症的万能药？
Is accelerated, high-dose theta burst stimulation a panacea for treatment-resistant depression?
机构信息
Brain Stimulation Laboratory, Department of Psychiatry, Medical University of South Carolina, Charleston, South Carolina.
出版信息
J Neurophysiol. 2020 Jan 1;123(1):1-3. doi: 10.1152/jn.00537.2019. Epub 2019 Sep 25.
A recent study by Williams et al. (Williams NR, Sudheimer KD, Bentzley BS, Pannu J, Stimpson KH, Duvio D, Cherian K, Hawkins J, Scherrer KH, Vyssoki B, DeSouza D, Raj KS, Keller J, Schatzberg AF. 141: e18, 2018) used accelerated, high-dose intermittent theta burst stimulation (iTBS) to treat highly treatment-resistant depression patients. Remarkably, most patients remitted, but the durability of therapeutic response was weak and all patients relapsed within 2 wk posttreatment. This mini-review examines the "fast on, fast off" effects of accelerated, high-dose iTBS for depression and suggests a new treatment that would combine the strengths of multiple extant iTBS protocols.
威廉姆斯等人最近的一项研究（Williams NR, Sudheimer KD, Bentzley BS, Pannu J, Stimpson KH, Duvio D, Cherian K, Hawkins J, Scherrer KH, Vyssoki B, DeSouza D, Raj KS, Keller J, Schatzberg AF. 141: e18, 2018）使用加速、高剂量的间歇性 theta 爆发刺激（iTBS）治疗高度难治性抑郁症患者。值得注意的是，大多数患者缓解，但治疗反应的持久性较弱，所有患者在治疗后 2 周内均复发。这篇小型综述探讨了加速、高剂量 iTBS 治疗抑郁症的“快速起效，快速失效”效应，并提出了一种新的治疗方法，该方法将结合多种现有 iTBS 方案的优势。
Zotero 插件