Vlok Marli, Majer Anna
Enterovirus and Enteric Viruses Laboratory, Viral Disease, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada.
Department of Medical Microbiology and Infectious Diseases, College of Medicine, Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 3R2, Canada.
Microorganisms. 2025 Aug 1;13(8):1801. doi: 10.3390/microorganisms13081801.
Non-polio enteroviruses continue to cause numerous epidemics world-wide that range from mild to severe disease, including acute flaccid paralysis, meningitis, severe respiratory infections and encephalitis. Using publicly available data we present a comprehensive global and regional temporal distribution of non-polio enteroviruses, with a focus on highly prevalent genotypes. We found that regional distribution did vary compared to global prevalence where the top prevalent genotypes included CVA6 and EV-A71 in Asia, EV-D68 in North America and CVA13 in Africa, while E-30 was prevalent in Europe, South America and Oceania. In 2020, the COVID-19 pandemic did interrupt non-polio enterovirus detections globally, and cases rebounded in subsequent years, albeit at lower prevalence and with decreased genotype diversity. Environmental surveillance for non-polio enteroviruses does occur and has been used in some regions as an early-warning system; however, further development is needed to effectively supplement potential gaps in clinical surveillance data. Overall, monitoring for non-polio enteroviruses is critical to identify true incidence, improve understanding of genotype circulation, provide an early warning system for emerging/re-emerging genotypes and allow for better outbreak control.
非脊髓灰质炎肠道病毒继续在全球引发众多疫情，这些疫情涵盖从轻度到重度的疾病，包括急性弛缓性麻痹、脑膜炎、严重呼吸道感染和脑炎。利用公开可得的数据，我们呈现了非脊髓灰质炎肠道病毒全面的全球和区域时间分布情况，重点关注高度流行的基因型。我们发现，与全球流行情况相比，区域分布确实存在差异，其中亚洲最流行的基因型包括CVA6和肠道病毒A71型（EV-A71），北美是肠道病毒D68型（EV-D68），非洲是CVA13，而E-30在欧洲、南美洲和大洋洲流行。2020年，新冠疫情确实中断了全球非脊髓灰质炎肠道病毒的检测，随后几年病例数出现反弹，尽管流行率较低且基因型多样性有所下降。对非脊髓灰质炎肠道病毒进行环境监测确实存在，并且在一些地区已被用作预警系统；然而，需要进一步发展以有效弥补临床监测数据中的潜在缺口。总体而言，对非脊髓灰质炎肠道病毒的监测对于确定真实发病率、增进对基因型传播的了解、为新出现/再次出现的基因型提供预警系统以及实现更好的疫情控制至关重要。
