Extract Attenuates Ethanol-induced Renal Damage by Reducing Oxidative Stress and Lipid Peroxidation in Rats.

BACKGROUND

Alcohol consumption is capable of producing free radicals and inducing disturbance in body antioxidant. () is a vegetable and it has beneficial antioxidant effects.

MATERIALS AND METHODS

Forty-eight Wistar rats were divided randomly into eight groups ( = 6): control normal (saline) and ethanol (5g EtOH/kg body weight/24h) control groups, groups (50, 100, and 150mg/kg), and + ethanol treated groups (50, 100, and 150mg/kg). Treatments were administered intraperitoneally and through gavage daily for 12 weeks. Parameters related to the function and the histology of the kidneys were evaluated and statistically analyzed from kidney and blood serum samples with respect to the groups.

RESULTS

Ethanol administration increased significantly Bowman's space, qualitative histopathology indices, kidney malondialdehyde (MDA) level, blood urea nitrogen (BUN), creatinine, and nitrite oxide levels and decreased significantly total antioxidant capacity (TAC) level and diameter and number of renal corpuscles compared to that in the control normal group ( < 0.001). The and + ethanol treatments in a dose-dependent manner reduced significantly Bowman's space, qualitative histopathology indices, kidney MDA level, BUN, creatinine, and nitrite oxide levels and increased significantly TAC level and diameter and number of renal corpuscles compared to that in the ethanol normal group ( < 0.001).

CONCLUSION

It seems that administration in a dose-dependent manner improved kidney injury induced by ethanol in rats.