Jalili Cyrus, Kamani Mehran, Roshankhah Shiva, Sadeghi Hamid, Salahshoor Mohammad Reza
Department of Anatomical Sciences, Medical School, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Andrologia. 2018 Dec;50(10):e13130. doi: 10.1111/and.13130. Epub 2018 Sep 2.
Diabetes causes a systemic inflammatory response with increased oxidative stress and can adversely effect spermatogenesis. Sickle-weed plant, scientifically called Falcaria vlugaris, contains antioxidants and antimicrobial ingredients. The aim of this study was to determine the effect of Falcaria vulgaris vulgaris extract on the sperm parameters of diabetic rats. In this experimental study, diabetes was induced in the animals using streptozotocin (STZ; 60 mg/kg). Sixty-four rats were equally divided into eight groups as follows: nondiabetic (normal) controls; normal rats given 50, 100 or 150 mg/kg doses of F. vulgaris extract; diabetic controls induced by STZ; and diabetic animals that received STZ plus 50, 100 or 150 mg/kg F. vulgaris extract. The animals were injected with the extract intraperitoneally once a day for 28 consecutive days. The sperm parameters of count, motility, morphology, viability, total antioxidant capacity and seminiferous tube diameter were analysed and compared. The results indicated that the values of all parameters decreased significantly in the diabetic control groups compared to the normal control group (p < 0.00). The parameters of the diabetic groups that received 50, 100 or 150 mg/kg F. vulgaris extract showed significant increases in all parameters at all doses compared to the diabetic control group (p ≤ 0.001). The administration of F. vulgaris extract as a potent antioxidant was able to compensate for the toxicity induced by STZ and increase the quality of some spermatozoa.
糖尿病会引发全身性炎症反应，增加氧化应激，对精子发生产生不利影响。镰叶草，科学名称为Falcaria vlugaris，含有抗氧化剂和抗菌成分。本研究的目的是确定镰叶草提取物对糖尿病大鼠精子参数的影响。在这项实验研究中，使用链脲佐菌素（STZ；60毫克/千克）诱导动物患糖尿病。64只大鼠平均分为八组，如下：非糖尿病（正常）对照组；给予50、100或150毫克/千克剂量镰叶草提取物的正常大鼠；由STZ诱导的糖尿病对照组；以及接受STZ加50、100或150毫克/千克镰叶草提取物的糖尿病动物。连续28天每天给动物腹腔注射提取物一次。分析并比较精子的数量、活力、形态、存活率、总抗氧化能力和生精小管直径等参数。结果表明，与正常对照组相比，糖尿病对照组所有参数的值均显著降低（p < 0.00）。与糖尿病对照组相比，接受50、100或150毫克/千克镰叶草提取物的糖尿病组在所有剂量下所有参数均显著增加（p≤0.001）。给予镰叶草提取物作为一种有效的抗氧化剂能够补偿STZ诱导的毒性，并提高一些精子的质量。
