巨噬细胞衍生的外泌体通过其在糖尿病大鼠模型中的抗炎作用加速伤口愈合。
Macrophage-derived exosomes accelerate wound healing through their anti-inflammation effects in a diabetic rat model.
机构信息
School of Pharmacy, Jinzhou Medical University , Jinzhou , P R China.
Department of Histology and Embryology, Jinzhou Medical University , Jinzhou , P R China.
出版信息
Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):3793-3803. doi: 10.1080/21691401.2019.1669617.
Chronic, subclinical inflammation was often observed in the diabetic wound area, causing inadequate and delayed wound-healing effects by failing to initiate cell migration, proliferation, and extracellular matrix deposition. Therefore, we presented macrophage-derived exosomes (Exos) and explored their potential for inhibiting inflammation and accelerating diabetic wound healing in a skin defect, diabetic rat model. A thorough investigation demonstrated that Exos exerted anti-inflammatory effects by inhibiting the secretion of pro-inflammatory enzymes and cytokines. Furthermore, they accelerated the wound-healing process by inducing endothelial cell proliferation and migration to improve angiogenesis and re-epithelialization in diabetic wounds.
慢性、亚临床炎症常常出现在糖尿病伤口区域，导致细胞迁移、增殖和细胞外基质沉积不足和延迟，从而影响伤口愈合。因此，我们提出了巨噬细胞衍生的外泌体（Exos），并在皮肤缺损、糖尿病大鼠模型中探索了它们抑制炎症和加速糖尿病伤口愈合的潜力。深入研究表明，Exos 通过抑制促炎酶和细胞因子的分泌发挥抗炎作用。此外，它们通过诱导内皮细胞增殖和迁移来加速伤口愈合过程，从而改善糖尿病伤口的血管生成和再上皮化。
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