Zhang Liang, Lou Kecheng, Zhang Yunmeng, Leng Yuanjing, Huang Yuqing, Liao Xinxin, Liu Xiaoliang, Feng Shangzhi, Feng Guoqiang
Department of Urology, Jiujiang University Clinic College/Hospital, Jiujiang, Jiangxi, China.
Department of Urology, Lanxi People's Hospital, Jinhua, Zhejiang, China.
Front Endocrinol (Lausanne). 2024 Dec 10;15:1510712. doi: 10.3389/fendo.2024.1510712. eCollection 2024.
Metabolic diseases have gradually become one of the most significant global medical burdens. Diseases such as obesity, diabetes, and metabolic syndrome, along with their complications, are clinically categorized as metabolic diseases. Long-term oral medication significantly reduces patient compliance and quality of life. Therefore, alternative therapies that intervene at the cellular level or target the root causes of metabolic diseases might help change this predicament. Research has found that extracellular vesicles derived from adipose macrophages can effectively regulate metabolic diseases by influencing the disease's development. This regulation is likely related to the role of these extracellular vesicles as important mediators in modulating adipose tissue function and insulin sensitivity, and their involvement in the crosstalk between adipocytes and macrophages. This review aims to describe the regulation of metabolic diseases mediated by adipose macrophage-derived extracellular vesicles, with a focus on their involvement in adipocyte crosstalk, the regulation of metabolism-related autoimmunity, and their potential as therapeutic agents for metabolic diseases, providing new avenues for diagnosis and treatment.
代谢性疾病已逐渐成为全球最重大的医疗负担之一。肥胖、糖尿病和代谢综合征等疾病及其并发症，在临床上被归类为代谢性疾病。长期口服药物会显著降低患者的依从性和生活质量。因此，在细胞水平上进行干预或针对代谢性疾病根源的替代疗法，可能有助于改变这种困境。研究发现，源自脂肪组织巨噬细胞的细胞外囊泡可以通过影响疾病的发展来有效调节代谢性疾病。这种调节可能与这些细胞外囊泡作为调节脂肪组织功能和胰岛素敏感性的重要介质的作用有关，以及它们参与脂肪细胞与巨噬细胞之间的相互作用。本综述旨在描述由脂肪组织巨噬细胞衍生的细胞外囊泡介导的代谢性疾病的调节，重点关注它们在脂肪细胞相互作用中的参与、对代谢相关自身免疫的调节，以及它们作为代谢性疾病治疗剂的潜力，为诊断和治疗提供新途径。
