Cserni Gábor, Serfozo Orsolya, Ambrózay Éva, Markó László, Krenács László
Institute of Pathology, University of Szeged, Szeged, Hungary.
Breast Imaging Unit, Mamma Rt, Kecskemét, Hungary.
Pol J Pathol. 2019;70(2):139-143. doi: 10.5114/pjp.2019.87105.
We report on a breast carcinoma with medullary features diagnosed by core needle biopsy in a 72-year-old woman. Both the primary tumour and its fine needle aspiration-proven, rapidly growing axillary metastasis regressed completely in less than 2 months, by the time surgery was performed. The biopsy of the primary tumour demonstrated a dense stromal infiltrate of CD8+/granzyme B+ activated cytotoxic T-cells suggestive of a robust antitumour immune response. Paradoxically, both tumour cells and tumour infiltrating immune cells demonstrated a diffuse PD-L1 expression, revealing that antitumour immune response has the ability to spontaneously overcome inhibitory mechanisms induced by cancerous growth.
我们报告了一例经粗针活检诊断为具有髓样特征的乳腺癌的72岁女性患者。在进行手术时，原发肿瘤及其经细针穿刺证实的快速生长的腋窝转移灶在不到2个月的时间内完全消退。原发肿瘤活检显示CD8+/颗粒酶B+活化细胞毒性T细胞的致密基质浸润，提示强大的抗肿瘤免疫反应。矛盾的是，肿瘤细胞和肿瘤浸润免疫细胞均表现出弥漫性PD-L1表达，表明抗肿瘤免疫反应有能力自发克服癌性生长诱导的抑制机制。
