镍催化的未活化烯烃的双官能化反应，由未稳定烯醇盐引发。
Nickel-Catalyzed Difunctionalization of Unactivated Alkenes Initiated by Unstabilized Enolates.
机构信息
Department of Chemistry , Yale University , 225 Prospect Street , New Haven , Connecticut 06520-8107 , United States.
出版信息
J Am Chem Soc. 2019 Oct 16;141(41):16249-16254. doi: 10.1021/jacs.9b09245. Epub 2019 Oct 2.
PMID:31556612
Abstract
This report demonstrates the possibility of a nickel-catalyzed difunctionalization of unactivated alkenes initiated by an unstabilized enolate nucleophile. The process tolerates a diverse range of electrophiles, including aryl, heteroaryl, alkenyl, and amino electrophiles. An electron-deficient phosphine ligand and a tetrabutylammonium salt additive were crucial for promoting efficient vicinal difunctionalization.
摘要
本报告展示了镍催化的未稳定烯醇化物引发的非活化烯烃的双官能化反应的可能性。该过程可耐受多种亲电试剂，包括芳基、杂芳基、烯基和氨基亲电试剂。缺电子膦配体和四丁基铵盐添加剂对于促进有效的邻位双官能化反应至关重要。
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