AB 环工程化铁蛋白纳米笼在良性实验条件下进行药物装载。
AB loop engineered ferritin nanocages for drug loading under benign experimental conditions.
机构信息
Key Laboratory of Chemical Biology and Molecular Engineering of Education Ministry, Key Laboratory of Energy Conversion and Storage Materials of Shanxi Province, Institute of Molecular Science, Shanxi University, Taiyuan 030006, China.
Drug Discovery Center for Infectious Disease and State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin, People's Republic of China.
出版信息
Chem Commun (Camb). 2019 Oct 10;55(82):12344-12347. doi: 10.1039/c9cc05247j.
Human ferritin has been explored as a potential drug nanocarrier, but extreme conditions (pH ≤ 2.0) are required for the encapsulation of drugs. Here, by engineering the AB loop of ferritin, we obtained a new ferritin variant with no new pores, which can disassemble at pH 3.0 or 4.0 and reassemble at pH 7.0. Consequently, under mild conditions, drugs can be encapsulated within this new ferritin nanocage.
人铁蛋白已被探索作为一种潜在的药物纳米载体，但需要极端条件（pH ≤ 2.0）来封装药物。在这里，通过工程改造铁蛋白的 AB 环，我们获得了一种没有新孔的新型铁蛋白变体，它可以在 pH 3.0 或 4.0 下解体，并在 pH 7.0 下重新组装。因此，在温和条件下，药物可以封装在这种新型铁蛋白纳米笼内。
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