Mercer University School of Medicine, Savannah, Georgia.
Department of Neurosurgery, Stanford University School of Medicine, Stanford, Georgia.
Stem Cells Dev. 2020 Feb 15;29(4):187-197. doi: 10.1089/scd.2019.0187. Epub 2019 Oct 29.
Although research involving traumatic brain injury (TBI) has traditionally focused on the acute clinical manifestations, new studies provide evidence for chronic and progressive neurological sequelae associated with TBI, highlighting the risk of persistent, and sometimes life-long, consequences for affected patients. Several treatment modalities to date have demonstrated efficacy in experimental models. However, there is currently no effective treatment to improve neural structure repair and functional recovery of TBI patients. Optogenetics represents a potential molecular tool for neuromodulation and monitoring cellular activity with unprecedented spatial resolution and millisecond temporal precision. In this review, we discuss the conceptual background and preclinical evidence of optogenetics for neuromodulation, and translational applications for TBI treatment are considered.
虽然涉及创伤性脑损伤 (TBI) 的研究传统上集中在急性临床表现上，但新的研究为 TBI 相关的慢性和进行性神经后遗症提供了证据，突出了受影响患者持续存在的风险，有时甚至是终身的后果。迄今为止，已有几种治疗方式在实验模型中显示出疗效。然而，目前还没有有效的治疗方法来改善 TBI 患者的神经结构修复和功能恢复。光遗传学代表了一种潜在的分子工具，可用于神经调节和以空前的空间分辨率和毫秒级时间精度监测细胞活动。在这篇综述中，我们讨论了光遗传学用于神经调节的概念背景和临床前证据，并考虑了其在 TBI 治疗中的转化应用。
