Czarnetzki B M, Meentken J, Kolde G, Bröcker E B
J Am Acad Dermatol. 1985 Feb;12(2 Pt 1):253-9. doi: 10.1016/s0190-9622(85)80031-1.
In seven patients with delayed pressure urticaria, the dermal inflammatory infiltrate was analyzed in early (4-6 hours) and late (20-24 hours) wheals by light and electron microscopy and by histomorphometric and immunohistologic methods. Results were compared with findings in normal skin of patients and in wheals induced with concanavalin A and compound 48/80 injections in patients and five healthy volunteers. Pressure wheals were characterized by a mild mononuclear perivascular infiltrate and by patchy dermal infiltrates of eosinophils. Neutrophils were almost completely absent. The number of dermal mast cells was markedly increased in early wheals, whereas their number was decreased in late wheals. Numerous mast cells were degranulated in late wheals, as shown by electron microscopy. On immunohistologic analysis, the perivascular infiltrate consisted primarily of lymphocytes with the helper phenotype. Epidermal OKT6 Ia-positive Langerhans cells were of normal number. The local increase of mast cells, eosinophils, and helper T lymphocytes suggests that pressure wheals result from a cellular immune response to as-yet-unknown antigens that are generated at pressure sites.
对7例迟发性压力性荨麻疹患者，通过光镜和电镜以及组织形态计量学和免疫组织学方法，分析早期（4 - 6小时）和晚期（20 - 24小时）风团的真皮炎症浸润情况。将结果与患者正常皮肤以及患者和5名健康志愿者注射刀豆球蛋白A和48/80复合物诱导的风团中的发现进行比较。压力性风团的特征是轻度单核细胞血管周围浸润和散在的真皮嗜酸性粒细胞浸润。几乎完全没有中性粒细胞。早期风团中真皮肥大细胞数量明显增加，而晚期风团中其数量减少。电镜显示晚期风团中有大量肥大细胞脱颗粒。免疫组织学分析显示，血管周围浸润主要由具有辅助表型的淋巴细胞组成。表皮OKT6 Ia阳性朗格汉斯细胞数量正常。肥大细胞、嗜酸性粒细胞和辅助性T淋巴细胞的局部增加表明，压力性风团是对压力部位产生的未知抗原的细胞免疫反应所致。
