Natbony S F, Phillips M E, Elias J M, Godfrey H P, Kaplan A P
J Allergy Clin Immunol. 1983 Feb;71(2):177-83. doi: 10.1016/0091-6749(83)90096-9.
Skin biopsy specimens were obtained from 43 consecutive patients with chronic idiopathic urticaria and from seven normal controls. Of 43 patients, 42 had a non-necrotizing perivascular infiltrate composed primarily of mononuclear cells. There was no evidence of damage to vessel walls, of nuclear debris, or of extravasation of red blood cells, and most cells were seen around vessels rather than within the vessel wall. One patient had vasculitis with a neutrophilic infiltrate, nuclear debris, and positive immunofluorescence. Quantitative cell counts revealed four times the number of mononuclear cells and 10 times the number of mast cells in urticaria biopsy sites vs normal skin. Thus chronic urticaria is characterized by an accumulation of mononuclear cells and mast cells with mast cell degranulation presumably associated with hive formation. In our series, the characteristic lesion is not vasculitic. The stimulus responsible for the infiltration of skin with these cells is unknown.
从43例连续性慢性特发性荨麻疹患者及7名正常对照者身上获取了皮肤活检标本。43例患者中，42例有以单核细胞为主的非坏死性血管周围浸润。没有血管壁损伤、核碎片或红细胞外渗的证据，且大多数细胞见于血管周围而非血管壁内。1例患者患有血管炎，伴有嗜中性粒细胞浸润、核碎片及免疫荧光阳性。定量细胞计数显示，荨麻疹活检部位的单核细胞数量是正常皮肤的4倍，肥大细胞数量是正常皮肤的10倍。因此，慢性荨麻疹的特征是单核细胞和肥大细胞积聚，肥大细胞脱颗粒可能与风团形成有关。在我们的系列研究中，特征性病变并非血管炎性。导致这些细胞浸润皮肤的刺激因素尚不清楚。
