James W D, Leyden J J
J Am Acad Dermatol. 1985 Feb;12(2 Pt 1):319-24. doi: 10.1016/s0190-9622(85)80043-8.
Thirty-two patients with gram-negative folliculitis were treated with 0.47 to 1.0 mg/kg/day of isotretinoin. Serial microbiologic evaluations demonstrated rapid clearing of the face and nasal mucosa of gram-negative rods. The clinical response was rapid, complete, and induced prolonged remissions. Twenty-six of thirty-two patients developed Staphylococcus aureus nasal carriage by the end of the 20-week treatment course. Isotretinoin has decided advantages over previously reported therapies for gram-negative folliculitis.
32例革兰阴性菌性毛囊炎患者接受了每日0.47至1.0毫克/千克剂量的异维甲酸治疗。系列微生物学评估显示革兰阴性菌在面部和鼻粘膜迅速清除。临床反应迅速、完全，并诱导了长期缓解。在20周治疗疗程结束时，32例患者中有26例出现金黄色葡萄球菌鼻腔定植。对于革兰阴性菌性毛囊炎，异维甲酸比先前报道的治疗方法具有明显优势。
