Thomas Ancil George, Mohan Madhusudanan, Thomas Reji, Baby Finu Mathew
Senior Resident.
Professor, Pushpagiri Institute Of Medical Sciences And Research Centre, Thiruvalla, Kerala.
J Assoc Physicians India. 2019 Sep;67(9):94-95.
Anti NMDA receptor (NMDAR) antibody mediated limbic encephalitis is the most common type of autoimmune encephalitis. Nearly half of the females presenting with anti NMDAR encephalitis have associated ovarian teratoma. Almost all of them have positive anti NMDAR antibody. Here we present a case of ovarian teratoma associated limbic encephalitis, with clinical picture typical of anti NMDAR mediated encephalitis, who was found to be negative for the antiNMDAR antibody. Clinicians should not defer from investigating a case of suspected anti NMDAR encephalitis for ovarian teratoma, even if antibody is negative.
抗N-甲基-D-天冬氨酸受体(NMDAR)抗体介导的边缘叶脑炎是最常见的自身免疫性脑炎类型。出现抗NMDAR脑炎的女性中近一半伴有卵巢畸胎瘤。几乎所有患者抗NMDAR抗体均呈阳性。在此,我们报告一例卵巢畸胎瘤相关的边缘叶脑炎病例,其临床表现为典型的抗NMDAR介导的脑炎,但抗NMDAR抗体检测为阴性。即使抗体检测为阴性,临床医生也不应延迟对疑似抗NMDAR脑炎病例进行卵巢畸胎瘤的检查。