Hu Jiali, Li Ke, Li Zhanghuan, Gao Chao, Guo Fei, Wang Yingmei, Xue Fengxia
Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, Tianjin 300052, China.
Cancer Biol Med. 2019 Aug;16(3):462-474. doi: 10.20892/j.issn.2095-3941.2019.0062.
genes are transcription factors with roles in multiple biological processes, including cell differentiation, proliferation, and apoptosis. genes have also been shown to act as regulators and biomarkers in the progression of many different cancers, including gynecological cancers such as ovarian, cervical, and endometrial cancer. In this review, we summarize the contrasting regulatory roles of genes in different gynecological cancers, as promotors with high expression levels or as suppressors with low expression levels. Expression levels of genes were also identified as biomarkers of clinical features, including International Federation of Gynecology and Obstetrics stage, histopathologic grade together with disease-free survival, and treatment efficacy in patients with gynecological cancers. An understanding of the mechanisms whereby genes regulate the progression of gynecological cancers will aid in the development of novel diagnostic and therapeutic strategies, while analysis of expression levels will help to predict the prognosis of patients with gynecological cancers.
基因是在多种生物学过程中发挥作用的转录因子，这些过程包括细胞分化、增殖和凋亡。基因还被证明在许多不同癌症的进展中充当调节因子和生物标志物，包括妇科癌症，如卵巢癌、宫颈癌和子宫内膜癌。在本综述中，我们总结了基因在不同妇科癌症中的相反调节作用，即作为高表达水平的促进因子或低表达水平的抑制因子。基因的表达水平也被确定为临床特征的生物标志物，包括国际妇产科联合会分期、组织病理学分级以及无病生存期，还有妇科癌症患者的治疗效果。了解基因调节妇科癌症进展的机制将有助于开发新的诊断和治疗策略，而对基因表达水平的分析将有助于预测妇科癌症患者的预后。
