Given B D, Lee T H, Stone P H, Dzau V J
Arch Intern Med. 1985 Feb;145(2):281-5.
Nifedipine was used successfully in nine patients with refractory hypertension and left ventricular hypertrophy who had symptoms of congestive heart failure despite preserved left ventricular systolic function. The administration of 10 or 20 mg of nifedipine resulted in an acute decline in BP, from 211 +/- 8/105 +/- 6 mm Hg to 153 +/- 9/78 +/- 5 mm Hg. Six patients received nifedipine and one patient received long-term verapamil therapy (mean follow-up, 16 +/- 4 weeks). In addition to sustained BP control, signs and symptoms of congestive heart failure were greatly improved in all patients treated long term with calcium channel antagonists. No adverse reactions were reported, but a short duration of action limited their usefulness in some patients. Nifedipine seems to be particularly beneficial in this subgroup of severe hypertensive patients with heart failure presumably due to diastolic stiffness of the left ventricle.
硝苯地平成功用于9例难治性高血压和左心室肥厚患者，这些患者尽管左心室收缩功能正常，但仍有充血性心力衰竭症状。给予10或20毫克硝苯地平后，血压急剧下降，从211±8/105±6毫米汞柱降至153±9/78±5毫米汞柱。6例患者接受硝苯地平治疗，1例患者接受长期维拉帕米治疗（平均随访16±4周）。除了持续控制血压外，长期接受钙通道拮抗剂治疗的所有患者充血性心力衰竭的体征和症状均有显著改善。未报告不良反应，但作用持续时间短限制了其在某些患者中的应用。硝苯地平似乎对这一严重高血压合并心力衰竭亚组患者特别有益，可能是由于左心室舒张功能障碍所致。
