Key Lab of Health Chemistry and Molecular Diagnosis of Suzhou, Department of Polymer Science and Engineering, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P. R. China.
J Mater Chem B. 2019 Oct 16;7(40):6202-6209. doi: 10.1039/c9tb01472a.
The continuing emergence of antibiotic-resistant bacteria due to the excessive use of antibiotics has produced a strong demand for novel strategies and new materials that do not lead to bacterial resistance. In the present work silicon nanowire arrays modified with gold-silver alloy nanoparticles (SN-Au/Ag) was investigated as a photo-induced antibacterial material. It was shown that SN-Au/Ag can kill bacteria with high efficiency under sunlight in times of the order of a few minutes, and this is achieved through synergism between photothermal and photocatalytic effects. It appears that the combined effect of heat and reactive oxygen species (ROS) causes bacteria killing through damage to the cell membrane and leakage of cytoplasm contents. Both gold and silver in the alloy nanoparticles are required for the observed bactericidal action. Moreover, the SN-Au/Ag material can be "recycled" without loss of bactericidal activity. It is concluded that the silicon nanowire arrays modified with gold-silver alloy nanoparticles developed in this work has promise as an antibacterial nanomaterial for the development of novel antibiotics.
由于抗生素的过度使用，抗生素耐药菌不断出现，这产生了对新型策略和新材料的强烈需求，这些策略和材料不会导致细菌耐药性。在本工作中，研究了金-银合金纳米粒子修饰的硅纳米线阵列（SN-Au/Ag）作为光诱导抗菌材料。结果表明，SN-Au/Ag 可以在阳光下在几分钟的时间内高效杀死细菌，这是通过光热和光催化协同作用实现的。似乎热和活性氧（ROS）的联合作用通过破坏细胞膜和细胞质内容物泄漏导致细菌死亡。合金纳米粒子中的金和银都需要观察到杀菌作用。此外，SN-Au/Ag 材料可以“回收”而不会失去杀菌活性。结论是，本工作中开发的金-银合金纳米粒子修饰的硅纳米线阵列有望成为新型抗生素开发的抗菌纳米材料。
