Department of Orthopaedic Surgery, Bone and Joint Research Center, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, 333, Taiwan.
Institute of Applied Mechanics, National Taiwan University, Taipei, 106, Taiwan.
Sci Rep. 2017 Jun 9;7(1):3155. doi: 10.1038/s41598-017-03357-w.
In this study, we investigated the antibacterial activity of silver-coated gold nanoparticles (Au-Ag NPs) immobilized on cellulose paper. Ag NPs are known to have strong antibacterial properties, while Au NPs are biocompatible and relatively simple to prepare. We made the Au-Ag NPs using a facile process called Ag enhancement, in which Au NPs serve as the nuclei for precipitation of a Ag coating, the thickness of which can be easily controlled by varying the ratio of the reactants. After synthesis, electron microscopy showed that the Au-Ag NPs displayed a core-shell structure, and that they could be successfully immobilized onto a cellulose membrane by heat treatment. We then investigated the antibacterial properties of this NP-coated cellulose paper against E. coli JM109. The inhibition rate, growth curve, and AATCC 100 activity test showed that cellulose paper coated with 15 nm Au-Ag NPs possessed excellent antibacterial activity against E. coli JM109. These results suggest that Au-Ag NPs immobilized on cellulose paper could be a valuable antibacterial technology for applications such as food packaging, clothing, wound dressings, and other personal care products.
在这项研究中，我们研究了固定在纤维素纸上的银包金纳米粒子（Au-Ag NPs）的抗菌活性。Ag NPs 具有很强的抗菌性能，而 Au NPs 具有生物相容性且相对易于制备。我们使用一种称为 Ag 增强的简单方法制备了 Au-Ag NPs，其中 Au NPs 作为沉淀 Ag 涂层的核，通过改变反应物的比例可以很容易地控制 Ag 涂层的厚度。合成后，电子显微镜显示 Au-Ag NPs 呈现出核壳结构，并且可以通过热处理成功地固定在纤维素膜上。然后，我们研究了这种涂有 NP 的纤维素纸对大肠杆菌 JM109 的抗菌性能。抑制率、生长曲线和 AATCC 100 活性测试表明，涂有 15nm Au-Ag NPs 的纤维素纸对大肠杆菌 JM109 具有优异的抗菌活性。这些结果表明，固定在纤维素纸上的 Au-Ag NPs 可能成为一种有价值的抗菌技术，可应用于食品包装、服装、伤口敷料和其他个人护理产品等领域。
