退伍军人老龄化队列研究指数作为生理脆弱性衡量指标的优势与局限性。
Strengths and Limitations of the Veterans Aging Cohort Study Index as a Measure of Physiologic Frailty.
作者信息
Justice Amy C, Tate Janet P
机构信息
VA Connecticut Healthcare System, West Haven, Connecticut.
Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.
出版信息
AIDS Res Hum Retroviruses. 2019 Nov/Dec;35(11-12):1023-1033. doi: 10.1089/AID.2019.0136.
Abstract
The Veterans Aging Cohort Study Index (VACS Index) is an index comprised of routine clinical laboratory tests that accurately and generalizably predicts all-cause mortality among those living with and without HIV infection. Increasing evidence supports its use as a measure of physiologic frailty among those aging with HIV because of its associations with frailty related outcomes including mortality, hospitalization, fragility fractures, serious falls, pneumonia, cognitive decline, delirium, and functional decline. In this review, we explore the evidence supporting the validity (construct, correlative, and predictive), responsiveness, and feasibility of the VACS Index as an early indicator of physiologic frailty. We also consider its limitations.
摘要
退伍军人衰老队列研究指数（VACS指数）是一个由常规临床实验室检查组成的指数，它能准确且具有普遍性地预测感染和未感染艾滋病毒者的全因死亡率。越来越多的证据支持将其用作衡量感染艾滋病毒的老年人生理脆弱性的指标，因为它与包括死亡率、住院率、脆性骨折、严重跌倒、肺炎、认知衰退、谵妄和功能衰退等与脆弱性相关的结果有关。在本综述中，我们探讨了支持VACS指数作为生理脆弱性早期指标的有效性（结构效度、关联效度和预测效度）、反应性和可行性的证据。我们也考虑了它的局限性。
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2
Polypharmacy, Hazardous Alcohol and Illicit Substance Use, and Serious Falls Among PLWH and Uninfected Comparators.
J Acquir Immune Defic Syndr. 2019 Nov 1;82(3):305-313. doi: 10.1097/QAI.0000000000002130.
3
Geriatric Syndromes in Older Adults Living with HIV and Cognitive Impairment.
J Am Geriatr Soc. 2019 Sep;67(9):1913-1916. doi: 10.1111/jgs.16034. Epub 2019 Jun 26.
4
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PLoS One. 2019 May 9;14(5):e0215764. doi: 10.1371/journal.pone.0215764. eCollection 2019.
5
Instruments for the detection of frailty syndrome in older adults: A systematic review.
PLoS One. 2019 Apr 29;14(4):e0216166. doi: 10.1371/journal.pone.0216166. eCollection 2019.
6
Albumin, white blood cell count, and body mass index improve discrimination of mortality in HIV-positive individuals.
AIDS. 2019 Apr 1;33(5):903-912. doi: 10.1097/QAD.0000000000002140.
7
Association of Prescribed Opioids With Increased Risk of Community-Acquired Pneumonia Among Patients With and Without HIV.
JAMA Intern Med. 2019 Mar 1;179(3):297-304. doi: 10.1001/jamainternmed.2018.6101.
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Biomarkers of Inflammation Correlate With Clinical Scoring Indices in Human Immunodeficiency Virus-Infected Kenyans.
J Infect Dis. 2019 Jan 7;219(2):284-294. doi: 10.1093/infdis/jiy509.
9
HIV and Aging - Perhaps Not as Dramatic as We Feared?
Gerontology. 2018;64(5):446-456. doi: 10.1159/000489172. Epub 2018 Jun 15.
10
Changes in alcohol use associated with changes in HIV disease severity over time: A national longitudinal study in the Veterans Aging Cohort.
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