HIV 与衰老——或许并不如我们担心的那般严重？

HIV and Aging - Perhaps Not as Dramatic as We Feared?

机构信息

University Department of Medicine and Infectious Diseases Service, Kantonsspital Baselland, University of Basel, Bruderholz, Switzerland.

Division of Infectious Diseases and Hospital Epidemiology, Departments of Medicine and Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.

出版信息

Gerontology. 2018;64(5):446-456. doi: 10.1159/000489172. Epub 2018 Jun 15.

DOI:10.1159/000489172

PMID:29909411

Abstract

Ever since the introduction of highly active antiretroviral therapy (ART) in 1995, HIV infection has been linked to "metabolic" complications (insulin resistance, dyslipidemia, osteoporosis, and others). Studies suggested increased rates of myocardial infarction, renal insufficiency, neurocognitive dysfunction, and fractures in HIV-postitive patients. Even long-term suppression of HIV seemed to be accompanied by an excess of deleterious inflammation that could promote these complications. The aims of this viewpoint paper are to summarize recent data and to examine the possibility that the problem of aging-related morbidity in HIV might not be as dramatic as previously believed.

摘要

自 1995 年引入高效抗逆转录病毒疗法 (ART) 以来，HIV 感染与“代谢”并发症（胰岛素抵抗、血脂异常、骨质疏松症等）有关。研究表明，HIV 阳性患者的心肌梗死、肾功能不全、神经认知功能障碍和骨折的发生率增加。即使 HIV 长期得到抑制，似乎也伴随着有害炎症的过度增加，从而促进这些并发症的发生。本文的目的是总结最近的数据，并探讨 HIV 患者与年龄相关的发病率问题可能不像以前认为的那么严重的可能性。